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Media Category: x - Recorded Webinars

The Role of Microglia in Multiple Sclerosis: Implications for Treatment with Bruton’s Tyrosine Kinase Inhibitors

Written by ParadigMS Foundation on .

Microglia are increasingly recognised as central regulators of neuroinflammation in Multiple Sclerosis (MS). Beyond their traditional classification, advances in molecular biology have revealed a spectrum of functional states that influence both tissue damage and repair. This lecture provides a concise overview of microglial biology in MS and explores how emerging therapeutic strategies, particularly Bruton tyrosine kinase (BTK) inhibitors, may modulate these cells to impact disease progression. Key Insights from the Lecture: Microglia as central orchestrators of CNS immunity: Microglia...

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Prognostic Factors for Evaluation of MS Therapy in Treatment Naive Patients

Written by ParadigMS Foundation on .

Magd Zakaria presented a clinically oriented approach to integrating prognostic factors into early treatment decision-making in Multiple Sclerosis (MS). Building on current evidence and international guidelines, this keynote addresses a central question in MS management: how to balance early use of high-efficacy therapies with individual disease activity, patient characteristics, and healthcare system constraints. Key Insights from the Lecture: Disability progression in MS is primarily driven by progression independent of relapse activity (PIRA), which begins early in the disease...

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Pregnancy and Lactation in Multiple Sclerosis

Written by ParadigMS Foundation on .

Family planning is a core part of care in Multiple Sclerosis (MS), particularly because many patients are women of reproductive age. This webinar reviews the clinical considerations around conception, pregnancy, postpartum relapse risk, breastfeeding, and treatment selection. It also addresses how disease-modifying therapies can be used before, during, and after pregnancy to support both maternal disease control and informed reproductive decision-making. Learning Objectives After this webinar, participants should be able to: Explain why family planning should be discussed early in...

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MRI and the implications of the new diagnostic criteria

Written by ParadigMS Foundation on .

This webinar provides an expert overview of the revised diagnostic criteria for Multiple Sclerosis (MS), with a specific focus on their implications for magnetic resonance imaging (MRI) in clinical practice. Building on the 2017 framework, the updated criteria aim to improve diagnostic specificity while enabling earlier and more accurate identification of MS. The session reviews the key changes, including the introduction of new topographies and MRI biomarkers, and discusses how these elements can be integrated into routine clinical workflows. Through expert insights and clinical examples,...

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The Clinical Management of NMOSD in Belgium

Written by ParadigMS Foundation on .

Neuromyelitis optica spectrum disorder (NMOSD) is a rare but severe neuroinflammatory disease requiring rapid diagnosis and prompt treatment to prevent irreversible disability. In this expert-led webinar, Vincent van Pesch explores the latest advances in NMOSD diagnosis and management, with a particular focus on clinical practice in Belgium. The webinar is introduced and moderated by Melissa Cambron. The session covers diagnostic red flags, imaging features, antibody testing, and evolving therapeutic strategies that are reshaping patient care. Learning Objectives After watching...

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Real Life Experiences with Biosimilars

Written by ParadigMS Foundation on .

This expert-led webinar explored real-world experience with biosimilars in the treatment of Multiple Sclerosis (MS), with a particular focus on biosimilar natalizumab. Organized by ParadigMS, the session brought together Jelena Drulovic and Tjalf Ziemssen to discuss regulatory principles, clinical evidence, and practical challenges encountered in daily neurological practice. Professors reviewed the scientific and regulatory framework for biosimilars, emphasizing the concept of “totality of evidence” required for approval, including analytical, functional, pharmacokinetic, pharmacodynamic,...

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