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Media Category: x - Recorded Webinars

Immune reconstitution–pathology and pathway

Written by ParadigMS Foundation on .

In this keynote from Athens presented by Bart Van Wijmeersch, the concept of immune reconstitution therapy (IRT) in multiple sclerosis is examined from a mechanistic and clinical perspective. The presentation focuses on how targeted depletion and controlled repopulation of immune cells may rebalance dysregulated immunity, enhance tolerance, and reshape long-term disease activity. Key Insights from the Lecture: Immune reconstitution as a goal: restoring immune balance and tolerance is presented as a core objective in MS, by resetting dysregulated regulatory and effector cells. The...

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B-Cell Clinical aspects: available and future treatment

Written by ParadigMS Foundation on .

In this keynote delivered in Athens, Professor Carlo Pozzilli takes the audience through the past, present and future of anti-CD20 therapies in multiple sclerosis. Starting from the early interferon era and the first monoclonal antibodies, Professor Pozzilli retraces how B-cell depletion moved from a provocative concept to a central pillar of MS management. Drawing on pivotal trials, 10-year extension data and real-world evidence, the discussion adresses why starting high-efficacy therapy early matters, how anti-CD20 agents compare with other high-efficacy options such as natalizumab,...

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Immune reconstitution – Clinical aspects: available and future treatment

Written by ParadigMS Foundation on .

Immune reconstitution therapies are reshaping modern MS management, offering periods of lasting disease control without continuous immunosuppression. In this thought-provoking session, Prof. Patrick Vermersch, leading MS clinician and clinical trial expert, examines how IRTs work in real clinical practice, what drives long-term success, and how to navigate risks, patient selection, and treatment timing. Drawing on decades of research and clinical experience, Prof. Vermersch provides a clear and clinically meaningful framework for understanding cladribine, alemtuzumab, HSCT, and...

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Microglia – Clinical aspects: available and future treatment

Written by ParadigMS Foundation on .

In this educational session, Prof. Celia Oreja-Guevara explores the crucial role of microglia in multiple sclerosis and how our evolving understanding of these resident immune cells is reshaping approaches to disease monitoring and treatment. Professor Oreja-Guevara discusses how microglial activation contributes to lesion development, chronic inflammation, and disability progression, while highlighting emerging therapeutic strategies targeting neuroinflammation. With clear clinical relevance and a forward-looking perspective, this presentation is ideal for neurologists and clinicians...

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New insights in the 2024 McDonald criteria: imaging biomarkers shaping MS diagnosis

Written by ParadigMS Foundation on .

In this keynote lecture at the Belgian MS Symposium 2025, Pietro Maggi discussed how advanced MRI biomarkers have been integrated into the upcoming 2024 revisions of the McDonald diagnostic criteria for Multiple Sclerosis. Key Insights from the Webinar: These revisions aim to improve diagnostic precision and reduce misdiagnosis, particularly in early or atypical cases. Among the most significant updates are: Optic nerve involvement — now recognized as a fifth anatomical location for demonstrating dissemination in space (DIS), supported by MRI, visual evoked potentials (VEP), and...

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Translation of 2024 MS criteria for asymptomatic individuals into clinical practice: From RIS to MS

Written by ParadigMS Foundation on .

This recording will help you refine your MS diagnostic skills with Christine Lebrun-Frenay led-insights on the 2024 McDonald criteria and practical tools for confident early detection. Key Insights from the Webinar The 2024 McDonald revision refines diagnostic clarity in Multiple Sclerosis (MS) while maintaining strong continuity with the 2017 criteria. The update aims to support earlier, more confident diagnosis, particularly for asymptomatic or preclinical cases, and to reduce over-diagnosis in patients with vascular or migraine-related MRI findings. The session highlights how...

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