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Media Category: x - Recorded Webinars

NMOSD Panel Discussion: Pathophysiology, Monitoring, and Treatment Challenges

Written by ParadigMS Foundation on .

This expert panel discussion explores the current challenges in understanding and managing neuromyelitis optica spectrum disorder (NMOSD). Bringing together clinical perspectives, the conversation highlights gaps in pathophysiology, limitations in monitoring tools, and ongoing uncertainties in long-term treatment strategies. Despite advances in biomarkers and therapies, real-world decision-making remains largely driven by clinical experience. Key Insights from the Lecture: Antibodies alone are not sufficient to cause disease Clinical context remains essential T cells play a...

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Multiple Sclerosis and pregnancy: from planning to postpartum

Written by ParadigMS Foundation on .

Family planning is a central concern for women living with multiple sclerosis, as the disease often affects patients during their reproductive years. Questions around pregnancy, treatment safety, and postpartum relapse risk require careful, individualized planning. With the right multidisciplinary approach and treatment strategies, pregnancy can be safely managed while minimizing risks for both mother and child. Key Insights from the Lecture: Family planning is a key concern in MS care Pregnancies are not always planned Planning pregnancy reduces risks Multidisciplinary...

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The clinical management of NMOSD

Written by ParadigMS Foundation on .

Neuromyelitis optica spectrum disorder (NMOSD) is a rare but severe relapsing disease of the central nervous system, characterized by attacks that lead to cumulative disability. Unlike multiple sclerosis, progression is not continuous but driven by relapses, making early diagnosis and rapid treatment essential. Advances in biomarkers, classification, and targeted therapies are reshaping how clinicians approach NMOSD management. Key Insights from the Lecture: NMOSD is a rare but globally variable disease Disability is driven by relapses, not progression Aquaporin-4 antibodies...

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CSF in the new diagnostic criteria in multiple sclerosis

Written by ParadigMS Foundation on .

The diagnosis of multiple sclerosis (MS) has significantly evolved over time, moving from a purely clinical approach to a more integrated model combining imaging and biological markers. Among these, cerebrospinal fluid (CSF) analysis has regained a central role. Recent advances, particularly the use of kappa free light chains (KFLC), are transforming diagnostic practices by offering a faster, more accessible, and reliable alternative to traditional methods. Key Insights from the Lecture: CSF has long been essential in MS diagnosis Diagnostic criteria have evolved significantly MRI...

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The immunopathological hallmarks of neuromyelitis optica spectrum desorder (NMOSD)

Written by ParadigMS Foundation on .

Nikolaos Grigoriadis presents a keynote lecture on the pathophysiology of Neuromyelitis Optica Spectrum Disorder (NMOSD), focusing on the immunological mechanisms underlying disease activity. The session provides clinically relevant insights into how these mechanisms translate into relapse patterns and therapeutic targets. Key Insights from the Lecture: NMOSD is a relapse-driven disease, with disability primarily resulting from acute attacks rather than progressive mechanisms Anti-aquaporin-4 antibodies are present in the majority of patients and play a central pathogenic role...

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How to detect progression in Multiple Sclerosis

Written by ParadigMS Foundation on .

Celia Oreja-Guevara presented a clinically focused overview of how to detect disease progression in Multiple Sclerosis (MS). As therapeutic advances increasingly target progression, this keynote highlights the need to move beyond traditional markers of inflammation and adopt a multidimensional approach integrating clinical assessment, imaging, cognition, and biomarkers. Key Insights from the Lecture: Disease progression in MS can occur independently of relapses and may remain undetected using conventional inflammatory markers. Patients may continue to accumulate disability despite...

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