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Paediatric Multiple Sclerosis

Written by ParadigMS Foundation on .

Pediatric-onset Multiple Sclerosis is rare, but early recognition and appropriate treatment are critical. Explore expert guidance on differential diagnosis, biomarkers, disease progression and treatment strategies in children with MS. Pediatric-onset Multiple Sclerosis (MS) accounts for a small proportion of MS cases, yet its early onset can lead to substantial disability at a young age. Accurate diagnosis can also be challenging, particularly when distinguishing MS from Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD), acute disseminated encephalomyelitis (ADEM) and other...

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Generics and biosimilars in Multiple Sclerosis: understanding efficacy, safety and clinical confidence

Written by ParadigMS Foundation on .

Generics and biosimilars are becoming increasingly relevant in Multiple Sclerosis (MS) care as more follow-on treatments enter clinical practice. In this keynote, Thomas Berger explains how generics and biosimilars differ, how they are evaluated and approved, and why regulatory quality, bioequivalence, immunogenicity and pharmacovigilance are central to confidence in their use. Key Insights from the Lecture: Generics and biosimilars are already established in other areas of neurology, but their use in Multiple Sclerosis remains relatively recent. A major concern among both...

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Multiple Sclerosis and pregnancy: balancing treatment, safety and family planning

Written by ParadigMS Foundation on .

Pregnancy and family planning remain important considerations in the management of Multiple Sclerosis (MS), particularly as treatment options become more effective and diverse. In this expert session, Thomas Berger reviews how different disease-modifying therapies (DMTs) can influence decisions before, during and after pregnancy, and highlights the importance of evidence-based counselling, individualized treatment planning and careful consideration of breastfeeding. Key Insights from the Lecture: Pregnancy itself is not presented as the main risk for women with Multiple...

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Central vein sign and paramagnetic rim lesions in Multiple Sclerosis diagnosis

Written by ParadigMS Foundation on .

New MRI biomarkers are becoming increasingly relevant in the diagnosis of Multiple Sclerosis (MS). Among them, the central vein sign (CVS) and paramagnetic rim lesions (PRLs) can improve diagnostic specificity and help distinguish MS from conditions that may mimic the disease. Šarlota Mesaroš reviews the biological basis, MRI detection and clinical relevance of these two biomarkers, and explains how they are incorporated into the revised McDonald diagnostic criteria. Key Insights from the Lecture: The central vein sign reflects a characteristic pathobiological feature of...

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Radiologically Isolated Syndrome: from incidental findings to preclinical Multiple Sclerosis

Written by ParadigMS Foundation on .

Radiologically Isolated Syndrome (RIS) is becoming increasingly relevant as Multiple Sclerosis (MS) diagnosis moves from a purely clinical model toward a more biologically informed framework. In this keynote, Cecilia Rajda explores how the 2024 diagnostic criteria are reshaping the definition of RIS, which patients may now fulfil criteria for MS, and what this means for diagnostic work-up, follow-up, treatment decisions and communication with patients. Key Insights from the Lecture: Multiple Sclerosis may begin biologically before the first clinical symptoms appear. RIS...

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Detecting progression in Multiple Sclerosis: practical approaches and emerging tools

Written by ParadigMS Foundation on .

Progression in Multiple Sclerosis (MS) can begin early and may continue even in the absence of relapses or new MRI lesions. Detecting these changes sooner is becoming increasingly relevant as new therapeutic options for progression emerge. In this keynote, Celia Oreja-Guevara explores how progression can be identified in clinical practice through a combination of patient-reported changes, functional assessment, cognition, MRI, optical coherence tomography (OCT), fluid biomarkers and digital tools. Key Insights from the Lecture: Progression can occur from the early stages of...

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