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Media Category: x - Recorded Webinars

2024 McDonald Criteria: what changes for Multiple Sclerosis diagnosis?

Written by ParadigMS Foundation on .

The 2024 revisions of the McDonald Diagnostic Criteria introduce important changes designed to support earlier and more consistent diagnosis of Multiple Sclerosis (MS). Gregor Brecl Jakob explains the clinical rationale behind the revisions, including the incorporation of selected patients with Radiologically Isolated Syndrome (RIS), a unified diagnostic approach for relapsing and primary progressive MS, and the inclusion of the optic nerve as a fifth topography for demonstrating dissemination in space. Key Insights from the Lecture: The 2024 criteria move closer to a biologically...

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New diagnostic criteria in MS: The evolving role of biomarkers in Multiple Sclerosis

Written by ParadigMS Foundation on .

This expert panel discussion explores the current challenges in understanding and managing neuromyelitis optica spectrum disorder (NMOSD). Bringing together clinical perspectives, the conversation highlights gaps in pathophysiology, limitations in monitoring tools, and ongoing uncertainties in long-term treatment strategies. Despite advances in biomarkers and therapies, real-world decision-making remains largely driven by clinical experience. Key Insights from the Lecture: Neurofilaments and GFAP are not specific to Multiple Sclerosis and should not replace established diagnostic...

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Patrick Vermersch: Detecting progression independent of relapse activity in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview In this interview, Patrick Vermersh discusses how clinicians can identify subtle progression through detailed patient questioning, multidimensional clinical assessment, advanced imaging and selected biomarkers. Key points discussed include: Why early detection of PIRA is important for anticipating further disability progression. The need to ask targeted questions about fatigue, walking, sensory symptoms, work, family life and daily activities. The limitations of relying on the Expanded Disability Status Scale (EDSS) alone. The value of assessing...

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Patrick Vermersch: Chronic Inflammation and PIRA in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview Progression independent of relapse activity (PIRA) is increasingly recognised as an important contributor to disability accumulation in Multiple Sclerosis (MS). In this interview, Patrick Vermersch explores the inflammatory mechanisms that may drive PIRA. He discusses the potential contributions of lymphocytes, microglia, astrocytes and other myeloid cells, as well as the challenges of evaluating chronic inflammation in vivo. Key points discussed include: The distinction between chronic inflammation associated with PIRA and focal inflammation associated...

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Early intervention in Multiple Sclerosis: the role of high-efficacy therapies in long-term outcomes

Written by ParadigMS Foundation on .

The treatment landscape for Multiple Sclerosis has expanded considerably, providing clinicians with a growing range of disease-modifying therapies. However, an important question remains: should treatment begin with a moderate-efficacy therapy and escalate when disease activity occurs, or should high-efficacy treatment be introduced earlier? This webinar examines the evidence behind both strategies, with a particular focus on the window of opportunity available during the early stages of Multiple Sclerosis. The speakers review how early intervention may influence relapse activity, disability...

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Long-term Efficacy and Safety of Anti-CD20 Therapies

Written by ParadigMS Foundation on .

Anti-CD20 therapies have transformed the treatment landscape of Multiple Sclerosis (MS), offering highly effective disease control through targeted B-cell depletion. As these therapies are increasingly used early in the disease course and maintained over many years, understanding their long-term efficacy, safety, and optimal use has become essential for clinical practice. In this webinar, Celia Oreja-Guevara and Patrick Vermersch review the latest evidence on anti-CD20 therapies, including ocrelizumab, ofatumumab, rituximab, and ublituximab. Drawing from pivotal clinical trials, extension...

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