Microglia – Clinical aspects: available and future treatment

In this educational session, Prof. Celia Oreja-Guevara explores the crucial role of microglia in multiple sclerosis and how our evolving understanding of these resident immune cells is reshaping approaches to disease monitoring and treatment. Professor Oreja-Guevara discusses how microglial activation contributes to lesion development, chronic inflammation, and disability progression, while highlighting emerging therapeutic strategies targeting neuroinflammation.

With clear clinical relevance and a forward-looking perspective, this presentation is ideal for neurologists and clinicians interested in how microglial biology is transforming present and future MS care.

Key Insights from the Lecture:

• Understanding how microglia contribute to inflammation, lesion formation, and MS progression.
• Clinical relevance of microglial activation in disability accumulation and treatment response.
• Current MS therapies with indirect effects on microglial activity.
• Emerging therapeutic approaches targeting microglia and chronic neuroinflammation.
• How microglia-focused research may influence future treatment strategies and patient outcomes.

“Clinical aspects of Microglia – available and future treatment“.

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About the speaker:

Celia Oreja-Guevara

Vice Chair of Neurology and Head of Multiple Sclerosis Center at the University Hospital San Carlos, Madrid

Professor Celia Oreja-Guevara is Vice Chair of Neurology and Head of Multiple Sclerosis Center at the University Hospital San Carlos, Madrid and Professor of Neurology at the University Complutense, Madrid, Spain.

After receiving her MD from the University Complutense, Madrid, Professor Oreja-Guevara completed a PhD in neuroimmunology at the Max-Planck-Institute for Neurobiology, University of Munich, Munich (Germany). She then went on to complete a residency in the Department of Neurology at the University of Bochum, Bochum (Germany) and a postdoctoral fellowship in neuroimaging at the University Hospital San Raffaele, Milan (Italy). She has also held posts at the University of Düsseldorf (Germany),Hospital de Fuenlabrada and at the University Hospital La Paz, both in Madrid.

Professor Oreja-Guevara’s research interests centre on family planning, menopause, clinical and neuroimaging correlations in MS and the use of optical coherence tomography. Neuromyelitis optica (NMO) is among her other therapy areas of interest, and Professor Oreja-Guevara is actively involved in the evaluation of new drugs for the treatment of MS and NMO. As an investigator, she has participated in a number of MS clinical trials and currently heads Paradigms, an independent and non-profit international group of Multiple Sclerosis experts. Currently, Professor Oreja-Guevara is an expert for the Spanish Medicines Agency and for the Scientific Advisory Group on Neurology of the European Medicines Agency.

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