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Media Category: Diagnosis

Rodica Bălaşa: Kappa Free Light Chains – A Practical, Objective Tool in CSF Analysis for MS

In this short interview, Rodica Bălaşa discusses how cerebrospinal fluid analysis in multiple sclerosis has evolved with the introduction of the kappa free light chain index. Watch the interview How have kappa free light chains improved cerebrospinal fluid evaluation in multiple sclerosis? In the interview, Rodica Bălaşa explains how cerebrospinal fluid evaluation in multiple sclerosis has evolved from a labor-intensive, subjective process to a more practical, quantitative, and cost-effective approach using kappa free light chains. Key points discussed include: The evolution...

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Rodica Bălaşa on Cerebrospinal Fluid as a diagnostic window in Multiple Sclerosis

Why does cerebrospinal fluid (CSF) remain an important tool in the diagnosis of multiple sclerosis, even with advances in imaging? Watch the interview In the interview, Rodica Bălaşa explains the ongoing importance of cerebrospinal fluid (CSF) evaluation in multiple sclerosis, emphasizing its role as a window into the brain’s pathological processes. Key points discussed include: The evolving role of CSF analysis in the diagnosis of multiple sclerosis Why CSF remains relevant despite advances in imaging and other non-invasive tools Its position within the 2024 McDonald criteria When...

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Thomas Berger: Paramagnetic Rim Lesions and Chronic Inflammation in Multiple Sclerosis

In this short video interview, Thomas Berger explains how insights from neuropathology and advanced MRI have improved our understanding of the long-term evolution of MS lesions. He describes paramagnetic rim lesions as markers of chronic, slowly expanding inflammation driven by microglia and iron accumulation, rather than inactive or “burned-out” scars. Watch the interview What do paramagnetic rim lesions reveal about chronic inflammation and disease progression in multiple sclerosis? In the interview, Thomas Berger focuses on what paramagnetic rim lesions represent biologically...

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Gregor Brecl Jakob on optic nerve involvement as a core topography in Multiple Sclerosis

In this short interview, Gregor Brecl Jakob discusses the role of the optic nerve as a key anatomical site in multiple sclerosis and its growing relevance in modern diagnostic criteria. Gregor explains why formally recognizing optic nerve involvement strengthens diagnostic sensitivity, supports earlier identification of MS, and reflects a more comprehensive understanding of disease dissemination. Watch the interview In the interview, Gregor Brecl Jakob explains how incorporating optic nerve involvement into diagnostic frameworks can strengthen MS diagnosis and support earlier clinical...

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Šarlota Mesaroš : Central Vein Sign – A Highly Specific MRI Biomarker for Multiple Sclerosis

In this short video interview, Šarlota Mesaroš discusses the role of the central vein sign as an advanced MRI biomarker in multiple sclerosis. While conventional MRI remains central to MS diagnosis, susceptibility-based imaging sequences now allow clinicians to visualize the venous origin of MS lesions. Šarlota highlights how the central vein sign, incorporated into the 2024 McDonald criteria, can support diagnosis and help distinguish MS from mimicking conditions, particularly when diagnostic uncertainty remains. Watch the interview What is the central vein sign, and why is it important...

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Thomas Berger: Using MRI Wisely in Multiple Sclerosis – Practical Guidance for Everyday Clinical Practice

In this short video interview, Thomas Berger explains how MRI should be used pragmatically in the diagnosis and monitoring of multiple sclerosis. Watch the interview How should MRI be used pragmatically in the diagnosis and monitoring of multiple sclerosis in everyday clinical practice? Key points discussed include: The need for MRI protocols that are practical, efficient, and accessible for the majority of patients worldwide The central role of typical morphological changes on MRI (especially T2 lesion burden) in establishing diagnosis The importance of identifying inflammatory...

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