Media Category: Diagnosis

In this short video interview, Thomas Berger explains how insights from neuropathology and advanced MRI have improved our understanding of the long-term evolution of MS lesions. He describes paramagnetic rim lesions as markers of chronic, slowly expanding inflammation driven by microglia and iron accumulation, rather than inactive or “burned-out” scars. Watch the interview What do paramagnetic rim lesions reveal about chronic inflammation and disease progression in multiple sclerosis? In the interview, Thomas Berger focuses on what paramagnetic rim lesions represent biologically...

In this short video interview, Šarlota Mesaroš discusses the role of the central vein sign as an advanced MRI biomarker in multiple sclerosis. While conventional MRI remains central to MS diagnosis, susceptibility-based imaging sequences now allow clinicians to visualize the venous origin of MS lesions. Šarlota highlights how the central vein sign, incorporated into the 2024 McDonald criteria, can support diagnosis and help distinguish MS from mimicking conditions, particularly when diagnostic uncertainty remains. Watch the interview What is the central vein sign, and why is it...