“Main difference between Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder (NMO-SD)?”
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“How can neurologist differentiate between Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorder (NMO-SD)?”
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ABSTRACT
In the past 20 years, the concept of antibody mediated demyelinating disorders have emerged. These diseases, namely Aquaporin-4 (AQP4) positive neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte (MOG)- antibody associated disease (MOGAD), share common features with multiple sclerosis, but are fundamentally different in terms of pathophysiology, disease course and treatment. In this lecture we will provide a clinical, biological and imaging description of these two entities, and propose a focus on the features that helps to differentiate in between these...
ABSTRACT
Over the last decade, knowledge of antibodies linked to inflammatory disorders of the central nervous system, including forms of neuromyelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis (ADEM), optic neuritis and transverse myelitis, has significantly reshaped the landscape of the diagnosis and clinical care. Notably, highly specific antibody assays have become an integral part of clinical decision making and include antibodies directed against the aquaporin-4 and anti–myelin oligodendrocyte glycoprotein (MOG).Various assays have been developed to...
BIOGRAPHY
Matthijs Oyaert
Matthijs Oyaert graduated as a master in drug development (pharmacy) in 2011 and master in clinical biology in 2016 at the KU Leuven and started working as a clinical biologist at the clinical laboratory of the Ghent University hospital. In the laboratory of clinical chemistry and hematology, he is responsible for a broad variety of (automated) routine clinical chemistry and immunochemistry tests and urinary test strip and particle analysis. In addition, he is involved in the laboratory diagnosis of auto-immune and neuroinflammatory diseases. During the...
BIOGRAPHY
Romain Marignier
Prof. Romain Marignier is a neurologist (MD), professor in the Neurological Hospital of Lyon, France. His field of expertise are the neuro-inflammatory disorders of the central nervous system with a specific interest on rare disorders, namely neuromyelitis optica spectrum disorders (NMOSD) and MOG-Ab associated diseases (MOGAD). Pr Marignier is the coordinator of the French nationwide NMO and MOGAD cohorts and biobanks, NOMADMUS, set up in 2010 that includes all the French clinical experts in neuro-inflammatory disorders. Through NOMADMUS, Pr Marignier...
ABSTRACT
Key take aways from this presentation on NMO and MS:
Rapidly evolving field, clinically/scientifically
Complex but reliable diagnostic criteria
Studies difficult (logistics, ethics, methodology): high likelihood to fail
High unmet need
Very close to “translation”
Major implications for understanding of more common disease multiple sclerosis
AUTHORS
PATRICK VERMERSCH
Patrick Vermersch studied medicine at Lille University Hospital (France), where he graduated in Neurology. Between 1990 and 1994 he pursued his training in basic research fields, mainly...
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