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Media Category: NMO

Astrocytes and myelin – pathology and pathway

Written by ParadigMS Foundation on .

Advances in antibody testing and biomarker-driven diagnostics have reshaped the distinction between Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorder (NMOSD), and MOG antibody-associated disease (MOGAD). Florian Deisenhammer reviews the historical shift from considering NMO a subtype of MS to recognizing NMOSD as a distinct antibody-mediated condition, and outlines how AQP4-IgG and MOG-IgG testing – together with characteristic MRI and CSF patterns – supports more accurate diagnosis. A central message is that these diseases can overlap clinically, but differ...

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Astrocytes and myelin – Clinical aspects: available and future treatment

Written by ParadigMS Foundation on .

This lecture explains how antibody-mediated pathology translates into clinical phenotypes and treatment strategies in Neuromyelitis Optica Spectrum Disorder (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD). Melinda Magyari contrasts the core targets, astrocytes (aquaporin-4) in NMOSD versus myelin/oligodendrocytes (MOG) in MOGAD, and shows how these mechanisms drive differences in relapse recovery, long-term disability, and therapeutic priorities. A major emphasis is placed on early antibody testing to avoid misdiagnosis (particularly as Multiple Sclerosis) and...

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Prof. Melinda Magyari on Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Written by ParadigMS Foundation on .

“Main difference between Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder (NMO-SD)?” * Please note that all the captions were generated automatically. If they do not appear, click on CC in the navigation. Interested in the next interview question? “How can neurologist differentiate between Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorder (NMO-SD)?” Log-in or subscribe. Curious to learn more about the expert behind this interview? Visit Melinda Magyari’s full biography for more insights...

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Differential Diagnosis in MS, NMO-SD and MOGAD

Written by ParadigMS Foundation on .

ABSTRACT In the past 20 years, the concept of antibody mediated demyelinating disorders have emerged. These diseases, namely Aquaporin-4 (AQP4) positive neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte (MOG)- antibody associated disease (MOGAD), share common features with multiple sclerosis, but are fundamentally different in terms of pathophysiology, disease course and treatment. In this lecture we will provide a clinical, biological and imaging description of these two entities, and propose a focus on the features that helps to differentiate in between these...

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Dr. Matthijs Oyaert – Lecture on Antibodies in Focus Advancements in Diagnosing NMO and MOG-related CNS Disorders

Written by ParadigMS Foundation on .

ABSTRACT Over the last decade, knowledge of antibodies linked to inflammatory disorders of the central nervous system, including forms of neuromyelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis (ADEM), optic neuritis and transverse myelitis, has significantly reshaped the landscape of the diagnosis and clinical care. Notably, highly specific antibody assays have become an integral part of clinical decision making and include antibodies directed against the aquaporin-4 and anti–myelin oligodendrocyte glycoprotein (MOG).Various assays have been developed to...

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Dr. Matthijs Oyaert on diagnostic tests used in the context of MS, NMO-SD, and MOGAD

Written by ParadigMS Foundation on .

BIOGRAPHY Matthijs Oyaert Matthijs Oyaert graduated as a master in drug development (pharmacy) in 2011 and master in clinical biology in 2016 at the KU Leuven and started working as a clinical biologist at the clinical laboratory of the Ghent University hospital. In the laboratory of clinical chemistry and hematology, he is responsible for a broad variety of (automated) routine clinical chemistry and immunochemistry tests and urinary test strip and particle analysis. In addition, he is involved in the laboratory diagnosis of auto-immune and neuroinflammatory diseases. During the...

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