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Managing MS in Individuals Aged 55 and Above 

Managing MS in older adults requires a tailored approach. In his latest presentation, Prof. Patrick Vermersch explores age-specific MS challenges, from immunosenescence and progressive disease to treatment strategies and discontinuation considerations.

  • Aging and Disease Progression: MS in older adults often shifts from a relapsing to a progressive form, with compartmentalized inflammation and microglial activation playing a central role.
  • Immunosenescence Considerations: Aging impacts immune function, increasing the risk of infections, especially with prolonged immunosuppressive therapy, necessitating a careful benefit-risk assessment in older patients.
  • Treatment Efficacy Variability: Many DMTs show reduced efficacy in older MS patients, emphasizing the importance of individualized treatment plans based on age and disease stage.
  • DMT Discontinuation Strategy: For some older patients, discontinuing DMTs may be an option when criteria such as stable disease activity (NEDA) and low EDSS are met, with careful monitoring afterward.
  • Comprehensive Care Approach: Managing MS in older adults requires addressing not only MS-specific symptoms but also age-related comorbidities and general health factors for optimal quality of life.

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Vice-president of Research in the fields of Life and Health Sciences at the University of Lille


Media

Details

  • Directors

    ParadigMS
  • Author(s)

    Patrick Vermersch
  • Country

    France
  • Release Date

    November 06, 2024
  • Views

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