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Media Type: Presentations

Symptomatic Therapies in Multiple Sclerosis | Part I

Key takeaways Symptomatic management is an essential component of Multiple Sclerosis (MS) care, addressing spasticity, ataxia, mobility impairment, tremor, sensory disturbances, and pain to improve daily functioning and quality of life. Spasticity affects approximately 60% of people with MS and can significantly impair mobility, sleep, and overall quality of life. Spasticity management requires a combination of pharmacological and non-pharmacological approaches, including rehabilitation, stretching, oral antispastic agents, nabiximols, botulinum toxin injections, and intrathecal...

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Real-Life Experiences with biosimilars 

Key takeaways Generics and biosimilars are increasingly relevant in Multiple Sclerosis (MS) as healthcare systems seek cost containment without compromising clinical outcomes. Biosimilars are not identical copies, but are rigorously evaluated to demonstrate high similarity to reference biologics in structure, efficacy, safety, and immunogenicity through the EMA/FDA “totality of evidence” framework. Clinical trials and real-world evidence consistently show comparable efficacy and safety between originator biologics and biosimilars used in MS, including interferon beta, rituximab...

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Managing MS in Individuals Aged 55 and Above 

Key takeaways Aging and Disease Progression: MS in older adults often shifts from a relapsing to a progressive form, with compartmentalized inflammation and microglial activation playing a central role. Immunosenescence Considerations: Aging impacts immune function, increasing the risk of infections, especially with prolonged immunosuppressive therapy, necessitating a careful benefit-risk assessment in older patients. Treatment Efficacy Variability: Many DMTs show reduced efficacy in older MS patients, emphasizing the importance of individualized treatment plans based on age and...

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Beyond EDSS: How to monitor disease progression in MS

Key takeaways Limitations of EDSS – The EDSS alone may not capture the full scope of MS progression, especially in cases where deterioration occurs independently of relapses (PIRA). Smoldering MS – MS can progress silently, with neurodegeneration happening beneath the surface, even when clinical symptoms seem stable. This requires a broader monitoring strategy. Multimodal Monitoring – Effective disease monitoring should go beyond neurological exams, integrating: Clinical assessments and patient-reported outcomes (PROs) Imaging techniques, such as MRI biomarkers and advanced...

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Cognition a marker for silent progression 2023

Cognitive impairment is a common marker of disease  progression and structural damage in strategic WM and GM regions explains cognitive impairment. AUTHOR CARLO POZZILLI Professor Pozzilli studied at the University of Rome “La Sapienza”. He then moved to the Hammersmith Hospital in London, UK, to take up a research post in 1980.In 1983, he became a Board Certified Neurologist at the University of Rome. In 1986 obtained a research grant in Neuroimaging at the Tohoku University, Sendai Japan.In 1987, he was awarded a PhD in Clinical Neurosciences by the University of...

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