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Media Category: Treatments

Endocannabinoid system – pathology and pathway

Written by ParadigMS Foundation on .

The endocannabinoid system represents a complex and independent neurotransmitter system with a central role in maintaining homeostasis within the nervous and immune systems. In this lecture, Nikolaos Grigoriadis reviewed the biological foundations of the endocannabinoid system, its mechanisms of action in the central nervous system and immune response, and the growing experimental and clinical evidence supporting its neuroprotective and immunomodulatory functions, with particular relevance for Multiple Sclerosis and other neuroinflammatory conditions. Key Insights from the Lecture: The...

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Endocannabinoid system – Clinical aspects: available and future treatment

Written by ParadigMS Foundation on .

In this keynote from Athens, medical cannabis is discussed as an emerging option for neuropathic pain and spasticity, with a particular focus on people living with multiple sclerosis. Evidence from clinical trials, large real-world cohorts and national prescribing data is reviewed, together with practical experience from a high-volume pain clinic. The presentation highlights how medical cannabis may reduce pain, spasticity and opioid use, while underlining current gaps in guidelines, regulatory hurdles and the need for careful titration and follow-up. Key Insights from the Lecture: Medical...

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Immune reconstitution–pathology and pathway

Written by ParadigMS Foundation on .

In this keynote from Athens presented by Bart Van Wijmeersch, the concept of immune reconstitution therapy (IRT) in multiple sclerosis is examined from a mechanistic and clinical perspective. The presentation focuses on how targeted depletion and controlled repopulation of immune cells may rebalance dysregulated immunity, enhance tolerance, and reshape long-term disease activity. Key Insights from the Lecture: Immune reconstitution as a goal: restoring immune balance and tolerance is presented as a core objective in MS, by resetting dysregulated regulatory and effector cells. The...

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B-Cell Clinical aspects: available and future treatment

Written by ParadigMS Foundation on .

In this keynote delivered in Athens, Professor Carlo Pozzilli takes the audience through the past, present and future of anti-CD20 therapies in multiple sclerosis. Starting from the early interferon era and the first monoclonal antibodies, Professor Pozzilli retraces how B-cell depletion moved from a provocative concept to a central pillar of MS management. Drawing on pivotal trials, 10-year extension data and real-world evidence, the discussion adresses why starting high-efficacy therapy early matters, how anti-CD20 agents compare with other high-efficacy options such as natalizumab, and...

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Translation of 2024 MS criteria for asymptomatic individuals into clinical practice: From RIS to MS

Written by ParadigMS Foundation on .

This recording will help you refine your MS diagnostic skills with Christine Lebrun-Frenay led-insights on the 2024 McDonald criteria and practical tools for confident early detection. Key Insights from the Webinar The 2024 McDonald revision refines diagnostic clarity in Multiple Sclerosis (MS) while maintaining strong continuity with the 2017 criteria. The update aims to support earlier, more confident diagnosis, particularly for asymptomatic or preclinical cases, and to reduce over-diagnosis in patients with vascular or migraine-related MRI findings. The session highlights how these...

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Prof. Thomas Berger on brain health.

Written by ParadigMS Foundation on .

Prof. Thomas Berger shares his perspective on brain health as a lifelong priority, not just in neurological disease but across the entire population. Speaking from EAN 2025 in Helsinki, he highlights why preserving brain health from childhood through older age is critical—and how neurologists can contribute to prevention, early detection, and proactive care in and beyond MS. “Brain health” Interested to see the interview? Log-in or subscribe Curious to learn more about the expert behind this interview? Visit Thomas Berger’s...

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