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Media Category: Treatments

E-learning | Real-life experience with biosimilars in multiple sclerosis

Biosimilars are becoming increasingly relevant in Multiple Sclerosis (MS) treatment, offering new opportunities for clinical practice. But how can healthcare professionals confidently integrate them into routine care? This e-learning provides practical insights into biosimilar natalizumab, covering regulatory approval, clinical evidence, switching strategies, safety monitoring, and patient communication to support informed treatment decisions. Access the e-learning What does this e-learning include? Expert presentations on the scientific and regulatory foundations of...

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E-learning | Early intervention in Multiple Sclerosis: the role of high-efficacy therapies in long-term outcomes (certified by Paradigms)

Treatment decisions made early in Multiple Sclerosis (MS) may have important implications for long-term neurological outcomes. But how does early high-efficacy treatment compare with traditional escalation strategies? This e-learning examines evidence from clinical trials, international registries and emerging biomarker research. Explore how treatment timing, disease activity and individual risk profiles can inform therapeutic decisions aimed at preserving long-term brain health. Access the e-learning What does this e-learning include? This 1-hour, self-paced course...

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Symptomatic Therapies in Multiple Sclerosis | Part I

Key takeaways Symptomatic management is an essential component of Multiple Sclerosis (MS) care, addressing spasticity, ataxia, mobility impairment, tremor, sensory disturbances, and pain to improve daily functioning and quality of life. Spasticity affects approximately 60% of people with MS and can significantly impair mobility, sleep, and overall quality of life. Spasticity management requires a combination of pharmacological and non-pharmacological approaches, including rehabilitation, stretching, oral antispastic agents, nabiximols, botulinum toxin injections, and intrathecal...

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Real-Life Experiences with biosimilars 

Key takeaways Generics and biosimilars are increasingly relevant in Multiple Sclerosis (MS) as healthcare systems seek cost containment without compromising clinical outcomes. Biosimilars are not identical copies, but are rigorously evaluated to demonstrate high similarity to reference biologics in structure, efficacy, safety, and immunogenicity through the EMA/FDA “totality of evidence” framework. Clinical trials and real-world evidence consistently show comparable efficacy and safety between originator biologics and biosimilars used in MS, including interferon beta, rituximab...

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Real Life Experiences with Biosimilars

This expert-led webinar explored real-world experience with biosimilars in the treatment of Multiple Sclerosis (MS), with a particular focus on biosimilar natalizumab. Organized by ParadigMS, the session brought together Jelena Drulovic and Tjalf Ziemssen to discuss regulatory principles, clinical evidence, and practical challenges encountered in daily neurological practice. Professors reviewed the scientific and regulatory framework for biosimilars, emphasizing the concept of “totality of evidence” required for approval, including analytical, functional, pharmacokinetic,...

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Astrocytes and myelin – Clinical aspects: available and future treatment

This lecture explains how antibody-mediated pathology translates into clinical phenotypes and treatment strategies in Neuromyelitis Optica Spectrum Disorder (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD). Melinda Magyari contrasts the core targets, astrocytes (aquaporin-4) in NMOSD versus myelin/oligodendrocytes (MOG) in MOGAD, and shows how these mechanisms drive differences in relapse recovery, long-term disability, and therapeutic priorities. A major emphasis is placed on early antibody testing to avoid misdiagnosis (particularly as Multiple Sclerosis)...

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Why should I subscribe to ParadigMS's e-platform?

Subscribing to ParadigMS’s e-platform gives you access to up-to-date information and valuable learning materials on multiple sclerosis and NMO, along with expert insights and the latest innovations in the field. It’s an essential resource for staying informed and enhancing your knowledge in MS care.

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Yes, you can financially support ParadigMS! We welcome donations to help us continue our mission of advancing multiple sclerosis education and research. Your contribution directly supports the creation of educational resources, expert discussions, and innovative projects in MS care. Visit our donation page to learn more about how you can make a difference: ParadigMS Donate.