In this short interview, Šarlota Mesaroš discusses the clinical relevance of paramagnetic rim lesions and their growing role in the diagnostic evaluation of multiple sclerosis.
Watch the interview
What is the clinical value of paramagnetic rim lesions in multiple sclerosis?
Šarlota Mesaroš presents a clear, practice-based overview of paramagnetic rim lesions and their relevance in the diagnosis of multiple sclerosis, drawing directly on advances in MRI imaging and current diagnostic criteria.
Key points discussed include:
- What paramagnetic rim lesions are and why they reflect chronic active inflammation in MS
- How advanced susceptibility-based MRI techniques enable their detection
- Their incorporation into the latest revision of the McDonald criteria
- In which clinical scenarios they may support dissemination in space
- Why they serve as a highly specific marker for MS, particularly when diagnostic uncertainty exists
- The importance of using these advanced imaging findings as an adjunct to clinical judgment rather than a standalone determinant
Throughout the interview, the focus remains on the appropriate and judicious use of advanced imaging markers, emphasizing their value as an adjunct to clinical judgment rather than a standalone diagnostic tool.
Could you explain what paramagnetic rim lesions are and why they are clinically significant?
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Key messages from Šarlota Mesaroš
Paramagnetic rim lesions represent highly specific imaging markers of chronic active inflammation in multiple sclerosis. In this interview, Šarlota Mesaroš explains how advances in MRI now allow clinicians to visualize these lesions and better characterize ongoing inflammatory activity.
Although not required to establish a diagnosis, their strength lies in their specificity, making them particularly valuable in cases where the distinction between MS and its mimics is uncertain. She also clarifies their position within the latest revision of the McDonald criteria, where they may support demonstration of dissemination in space in selected scenarios.
Overall, paramagnetic rim lesions should be viewed as a powerful adjunct to clinical judgment, enhancing diagnostic confidence without replacing established clinical and imaging principles.
Curious to learn more about the expert behind this interview?
Šarlota Mesaroš
Professor of Neurology at the Faculty of Medicine, University of Belgrade, Serbia
Consultant neurologist at the Department for immune-mediated CNS disorders, Neurology
Clinic, University Clinical Center of Serbia, Belgrade, Serbia.
Main field of research interest is diagnosis and treatment of MS and related disorders and
neuroimaging.
Vice-president of Serbian Neuroimmunology Society.
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