Improvement of measured and perceived disability in overweight patients with Multiple Sclerosis trough different patterns of Mediterranean hypocaloric diet.

Authors: Federica Felicetti ¹, Serena Ruggieri ², Ilaria Ruotolo ¹, Chiara Livi ¹, Giovanni Sellitto ³, Giorgia D’Ambrosi ¹, Riccardo Nistri ¹, Antonio Ianniello ³, Giovanna Borriello⁴, Carlo Pozzilli ³, Maria Petracca ⁵

¹MS Center, Sant’Andrea Hospital, Rome, Italy. ²Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. ³MS Center, Sant’Andrea Hospital, Rome, Italy; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. ⁴MS Center, Neurology Unit, Fatebenefratelli San Pietro Hospital, Rome, Italy. ⁵Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. Electronic address: maria.petracca@uniroma1.it.

Abstract

Objectives: 

Overweight and other cardiovascular risk factors are known contributors to disability accrual in Multiple Sclerosis (MS). We aimed to explore the impact of three hypocaloric dietetic patterns, based on the Mediterranean diet, on cardiovascular risk and clinical status in overweight persons with MS (pwMS).

Material and methods:

 Overweight pwMS (body mass index-BMI ≥25 kg/m²) were prospectively enrolled, randomly allocated to three hypocaloric dietetic plans differing in macronutrients composition (carbohydrates/proteins/lipids: diet A 65 %/15 %/20 %; diet B 35 %/25 %/40 %; diet C 50 %/20 %/30 %) and followed-up for 1 year (6 months of dietetic intervention + 6 months of observation). The Multiple Sclerosis Performance Test, a self-administered, iPad®-based system for quantifying cognition, upper and lower extremity motor function, and vision was performed at baseline, 6 and 12 months. Questionnaires for the evaluation of sleep quality, fatigue, anxiety, depression, stigma, social participation and satisfaction were administered. Information about cardiovascular risk parameters (BMI, waist circumference-WC, umbilical circumference-UC, hip circumference-HP, blood pressure, HDL and LDL cholesterol, triglycerides, glycemia) were collected. Adherence to the dietetic plan was quantified as days of complete to insufficient adherence across the treatment period. Between-group comparisons were performed with Chi-square and ANOVA; longitudinal analyses with one-way ANOVA for repeated measures and mixed-design ANOVA.

Results: 

Fifty-three patients completed the study (diet A n = 19, diet B n = 18, diet C n = 16). The three groups were well matched for sex, age, disease duration and EDSS. Along the 6 months of dietetic intervention, no difference in adherence was detected across the three dietetic plans (p = 0.84). Overall, patients showed a significant weight loss over time (p < 0.001) with no difference across diets (p = 0.34). BMI, WC, UC, HC and cholesterol improved over time (p ranging from 0.06 to 0.001), with no differences across diets (p ranging from 0.16 to 0.58). Among all tested clinical variables, fatigue, anxiety, information processing speed and manual dexterity improved significantly (p = 0.005, p = 0.012, p = 0.013, p = 0.005), with no differences across diets (p = 0.84, p = 0.89, p = 0.53, p = 0.72).

Conclusion: 

Dietetic interventions in overweight pwMS, irrespective of their specific macronutrients composition, are able to improve the cardiovascular profile, the perception of subjective symptoms as well as objective disability scores.

Keywords: 

Hypocaloric diet; Mediterranean diet; Multiple Sclerosis; objective disability; perceived disability.

Copyright © 2025 Elsevier B.V. All rights reserved.

The Article can be found on Science Direct website.

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