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Early intervention in Multiple Sclerosis: the role of high-efficacy therapies in long-term outcomes

This webinar reviews current evidence on early high-efficacy treatment strategies in Multiple Sclerosis, combining data from pivotal clinical trials, international registries and emerging biomarker research. It also examines progression independent of relapse activity (PIRA), smouldering disease processes and the importance of preserving long-term brain health when making treatment decisions.

The treatment landscape for Multiple Sclerosis has expanded considerably, providing clinicians with a growing range of disease-modifying therapies. However, an important question remains: should treatment begin with a moderate-efficacy therapy and escalate when disease activity occurs, or should high-efficacy treatment be introduced earlier?

This webinar examines the evidence behind both strategies, with a particular focus on the window of opportunity available during the early stages of Multiple Sclerosis. The speakers review how early intervention may influence relapse activity, disability accumulation, progression to secondary progressive Multiple Sclerosis and the preservation of neurological reserve.

After watching this webinar, participants will be able to:

  • Review clinical trial evidence comparing high- and moderate-efficacy therapies.
  • Examine real-world data on early intensive treatment and long-term disability outcomes.
  • Consider the role of biomarkers in treatment selection and prognosis.
  • Recognise progression independent of relapse activity and smouldering disease processes.
  • Assess how early intervention may support the preservation of long-term brain health.
  • Apply shared decision-making and individual risk–benefit assessment in clinical practice.

Please subscribe to watch.

Professor of Clinical Neuroscience at University Clinic Carl-Gustav Carus in Dresden

Associate Professor of Neurology at the University of Hasselt



Media

Details

  • Directors

    ParadigMS
  • Author(s)

    Tjalf Ziemssen and Bart Van Wijmeersch
  • Country

    Germany and Belgium
  • Release Date

    July 22, 2026
  • Views

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Subscribing to ParadigMS’s e-platform gives you access to up-to-date information and valuable learning materials on multiple sclerosis and NMO, along with expert insights and the latest innovations in the field. It’s an essential resource for staying informed and enhancing your knowledge in MS care.

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