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Media Category: x - Video Interview

Patrick Vermersch: Detecting progression independent of relapse activity in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview In this interview, Patrick Vermersh discusses how clinicians can identify subtle progression through detailed patient questioning, multidimensional clinical assessment, advanced imaging and selected biomarkers. Key points discussed include: Why early detection of PIRA is important for anticipating further disability progression. The need to ask targeted questions about fatigue, walking, sensory symptoms, work, family life and daily activities. The limitations of relying on the Expanded Disability Status Scale (EDSS) alone. The value of assessing...

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Magd Zakaria: Recognising Typical and Atypical Presentations in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview Magd Zakaria discusses the clinical features that can help distinguish typical presentations of Multiple Sclerosis from red flags suggestive of alternative demyelinating disorders. Visual, spinal cord and brainstem syndromes are among the most common clinical presentations at the onset of Multiple Sclerosis (MS), often occurring as a clinically isolated syndrome (CIS). In this interview, Magd Zakaria reviews the characteristic features of these presentations and highlights findings that are atypical for MS. He explains how symptom severity, bilateral involvement,...

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Magd Zakaria: Prognostic Factors in Multiple Sclerosis: Supporting Early Treatment Decisions

Written by ParadigMS Foundation on .

Watch the interview Selecting the most appropriate treatment at diagnosis requires an accurate assessment of disease activity and prognosis. In this interview, Magd Zakaria discusses a practical scoring system that combines demographic, clinical and MRI characteristics to help stratify treatment-naïve patients according to their risk of disease progression and support informed therapeutic decisions. Key points discussed include: Why prognostic assessment remains essential when selecting an initial treatment strategy. The development of a practical scoring system based...

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Patrick Vermersch: Chronic Inflammation and PIRA in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview Progression independent of relapse activity (PIRA) is increasingly recognised as an important contributor to disability accumulation in Multiple Sclerosis (MS). In this interview, Patrick Vermersch explores the inflammatory mechanisms that may drive PIRA. He discusses the potential contributions of lymphocytes, microglia, astrocytes and other myeloid cells, as well as the challenges of evaluating chronic inflammation in vivo. Key points discussed include: The distinction between chronic inflammation associated with PIRA and focal inflammation associated...

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Gregor Brecl Jakob : Optic Nerve Involvement in MS – Avoiding Misdiagnosis

Written by ParadigMS Foundation on .

In this short video interview, Gregor Brecl Jakob discusses the critical need for caution when attributing optic nerve pathology to multiple sclerosis. While optic nerve involvement is acknowledged in the diagnostic criteria, he emphasizes that optic neuritis has a broad differential diagnosis and should never be assumed to be MS-related without careful evaluation. Watch the interview Why is careful differential diagnosis essential when assessing optic nerve pathology in suspected multiple sclerosis? Gregor Brecl Jakob explains how specific clinical, imaging, and ophthalmological...

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Rodica Bălaşa: The Role of CSF Analysis in Multiple Sclerosis Diagnosis – Balancing Non-Invasive Tools and Biomarkers

Written by ParadigMS Foundation on .

In this short interview, Rodica Bălaşa discusses the evolving role of cerebrospinal fluid (CSF) analysis in the diagnosis of multiple sclerosis, particularly in light of the 2024 revision of the McDonald criteria. Although non-invasive investigations remain central to the diagnostic work-up, CSF continues to serve as an important complementary tool in selected patients. Rodica also addresses how advances in kappa free light chain testing have renewed interest in this established biomarker when additional diagnostic clarity is needed. Watch the interview When is cerebrospinal fluid...

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