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Media Category: Clinical & Practice

2024 McDonald Criteria: applying the new diagnostic framework in clinical practice

Written by ParadigMS Foundation on .

The 2024 revision of the McDonald Criteria introduces several important changes designed to support earlier and more accurate diagnosis of Multiple Sclerosis (MS). Mario Habek reviews how the revised criteria can be applied in clinical practice, including the incorporation of Radiologically Isolated Syndrome (RIS), the optic nerve as a fifth topography, kappa free light chains in cerebrospinal fluid analysis, and new MRI markers such as the central vein sign and paramagnetic rim lesions. Key Insights from the Lecture: Radiologically Isolated Syndrome can now meet diagnostic...

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2024 McDonald Criteria: what changes for Multiple Sclerosis diagnosis?

Written by ParadigMS Foundation on .

The 2024 revisions of the McDonald Diagnostic Criteria introduce important changes designed to support earlier and more consistent diagnosis of Multiple Sclerosis (MS). Gregor Brecl Jakob explains the clinical rationale behind the revisions, including the incorporation of selected patients with Radiologically Isolated Syndrome (RIS), a unified diagnostic approach for relapsing and primary progressive MS, and the inclusion of the optic nerve as a fifth topography for demonstrating dissemination in space. Key Insights from the Lecture: The 2024 criteria move closer to a...

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Magd Zakaria: Recognising Typical and Atypical Presentations in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview Magd Zakaria discusses the clinical features that can help distinguish typical presentations of Multiple Sclerosis from red flags suggestive of alternative demyelinating disorders. Visual, spinal cord and brainstem syndromes are among the most common clinical presentations at the onset of Multiple Sclerosis (MS), often occurring as a clinically isolated syndrome (CIS). In this interview, Magd Zakaria reviews the characteristic features of these presentations and highlights findings that are atypical for MS. He explains how symptom severity, bilateral...

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Magd Zakaria: Prognostic Factors in Multiple Sclerosis: Supporting Early Treatment Decisions

Written by ParadigMS Foundation on .

Watch the interview Selecting the most appropriate treatment at diagnosis requires an accurate assessment of disease activity and prognosis. In this interview, Magd Zakaria discusses a practical scoring system that combines demographic, clinical and MRI characteristics to help stratify treatment-naïve patients according to their risk of disease progression and support informed therapeutic decisions. Key points discussed include: Why prognostic assessment remains essential when selecting an initial treatment strategy. The development of a practical scoring system...

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CSF in the new diagnostic criteria in multiple sclerosis

Written by ParadigMS Foundation on .

The diagnosis of multiple sclerosis (MS) has significantly evolved over time, moving from a purely clinical approach to a more integrated model combining imaging and biological markers. Among these, cerebrospinal fluid (CSF) analysis has regained a central role. Recent advances, particularly the use of kappa free light chains (KFLC), are transforming diagnostic practices by offering a faster, more accessible, and reliable alternative to traditional methods. Key Insights from the Lecture: CSF has long been essential in MS diagnosis Diagnostic criteria have evolved...

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Prognostic Factors for Evaluation of MS Therapy in Treatment Naive Patients

Written by ParadigMS Foundation on .

Magd Zakaria presented a clinically oriented approach to integrating prognostic factors into early treatment decision-making in Multiple Sclerosis (MS). Building on current evidence and international guidelines, this keynote addresses a central question in MS management: how to balance early use of high-efficacy therapies with individual disease activity, patient characteristics, and healthcare system constraints. Key Insights from the Lecture: Disability progression in MS is primarily driven by progression independent of relapse activity (PIRA), which begins early in the...

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