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ParadigMS Expert Prof. Magd Zakaria co-authors study on predicting disease activity in relapsing-remitting MS

ParadigMS Foundation

By ParadigMS Foundation

January 23, 2025

We are delighted to share a new article Development and Validation of a Scoring System for Predicting Disease Activity in Treatment-Naïve Patients with Relapsing-Remitting Multiple Sclerosis co-authored by Prof. Magd Zakaria, a ParadigMS Foundation Board Member. This collaborative research, published in the journal Multiple Sclerosis and Related Disorders (MSARD Journal) on 16th January 2025, highlights significant findings that contribute to the growing body of knowledge on prognosis in multiple sclerosis (MS) management.

Relapsing-remitting multiple sclerosis (RRMS) presents substantial variability in disease expression and response to treatment. This complexity makes defining disease activity and predicting patient prognosis challenging. The newly developed “Scoring System for Disease Activity Prognosis in Treatment-Naïve RRMS Patients” (DAPS-RRMS) aims to address this challenge by providing a practical tool for guiding treatment decisions, particularly in resource-constrained settings.


Authors: Magd Zakaria1, Nevin Mohieldin Shalaby2, Farouk Talaat3, Alaa Elmazny 2,4 Eman Hamdy3, Mahmoud Saad Swelam1, Mohamed Kamal 5, Mahamad Taha 6,7, Madeg Abdel Naseer 2.

1. Neurology department, Ain Shams University, Cairo, Egypt, 2. Neurology department, Cairo University, Cairo, Egypt, 3. Neurology department, Alexandria University, Cairo, Egypt, 4. Internal Medicine Department, Arabian Gulf University, Bahrain, 5. Research Department, Children’s Cancer Hospital Egypt 57357, 6. Biostatistics Department, DataClin CRO, Cairo, Egypt, 7. Radiodiagnosis Department, Ain Shams University, Cairo, Egypt

Relapsing-remitting MS (RRMS) exhibits significant heterogeneity and different treatment responses. Up to date, there is no international consensus on defining disease activity which foretells potential prognosis. This study aims to develop and validate a “Scoring System for Disease Activity Prognosis in Treatment-Naïve RRMS Patients” (DAPS-RRMS) to help guiding treatment decisions.

A set of clinical and radiological factors predicting RRMS disease activity based on an extensive literature review were identified. Real-world data from 520 treatment-naïve RRMS patients were extracted from the Egyptian MS registry dataset by independent neurologists and were disseminated among a group of MS experts for evaluation of each case separately. To convert this clinical impression into a validated score, ordinal logistic regression was used to develop the scoring system and nomogram; validation was conducted using Receiver Operating Characteristic (ROC); interrater reliability was assessed using Kendall’s coefficient of concordance and the Intraclass Correlation Coefficient (ICC).

According to cut off values based on the sum of scores of involved parameters, patients were classified into four categories predicting disease activity, “Active” (0-9), “Highly Active” (9.5-14), “Very Highly Active” (14.5-19), and “Aggressive” (>19). The scoring tool demonstrated excellent performance metrics with high inter-rater agreement (Kendall’s W 0.764), and reliability including a high area under the curve (AUC) for discriminating between categories.

This validated scoring system provides a practical and reliable tool for predicting RRMS disease activity and guiding treatment decisions in treatment-naïve patients, particularly in resource-limited countries. The model is combined with a user-friendly nomogram.

The Article can be found on MSARD Journal website upon subscription.


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