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Media Category: Progressive MS

E-learning | Beyond EDSS: How to monitor disease progression in multiple sclerosis (Accredited by EACCME®)

Written by ParadigMS Foundation on .

Disease progression in Multiple Sclerosis (MS) can occur even in the absence of relapses, making early detection essential. But how can healthcare professionals identify subtle signs of progression that traditional assessment tools may miss? This e-learning explores a multimodal approach to monitoring MS progression, combining functional tests, advanced imaging, biomarkers, and patient-reported outcomes to support earlier detection and more personalised patient management. Access the e-learning What does this e-learning include? Expert insights into smouldering MS...

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E-learning | A practical guide: Uncovering disease progression in Multiple Sclerosis independent of relapse activity

Written by ParadigMS Foundation on .

Disease progression in Multiple Sclerosis (MS) can occur independently of relapses, making early detection and monitoring essential to improving long-term patient outcomes. But how can healthcare professionals recognise subtle signs of progression and translate emerging scientific insights into everyday clinical practice? Access the e-learning What does this e-learning include? This self-paced course, featuring 24 short videos of approximately 5-7 minutes each, includes: Expert presentations on disease progression, PIRA and the emerging concept of smouldering MS. ...

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Detecting progression in Multiple Sclerosis: practical approaches and emerging tools

Written by ParadigMS Foundation on .

Progression in Multiple Sclerosis (MS) can begin early and may continue even in the absence of relapses or new MRI lesions. Detecting these changes sooner is becoming increasingly relevant as new therapeutic options for progression emerge. In this keynote, Celia Oreja-Guevara explores how progression can be identified in clinical practice through a combination of patient-reported changes, functional assessment, cognition, MRI, optical coherence tomography (OCT), fluid biomarkers and digital tools. Key Insights from the Lecture: Progression can occur from the early stages of...

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Patrick Vermersch: Detecting progression independent of relapse activity in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview In this interview, Patrick Vermersh discusses how clinicians can identify subtle progression through detailed patient questioning, multidimensional clinical assessment, advanced imaging and selected biomarkers. Key points discussed include: Why early detection of PIRA is important for anticipating further disability progression. The need to ask targeted questions about fatigue, walking, sensory symptoms, work, family life and daily activities. The limitations of relying on the Expanded Disability Status Scale (EDSS) alone. The value of...

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Patrick Vermersch: Chronic Inflammation and PIRA in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview Progression independent of relapse activity (PIRA) is increasingly recognised as an important contributor to disability accumulation in Multiple Sclerosis (MS). In this interview, Patrick Vermersch explores the inflammatory mechanisms that may drive PIRA. He discusses the potential contributions of lymphocytes, microglia, astrocytes and other myeloid cells, as well as the challenges of evaluating chronic inflammation in vivo. Key points discussed include: The distinction between chronic inflammation associated with PIRA and focal inflammation...

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How to detect progression in Multiple Sclerosis

Written by ParadigMS Foundation on .

Celia Oreja-Guevara presented a clinically focused overview of how to detect disease progression in Multiple Sclerosis (MS). As therapeutic advances increasingly target progression, this keynote highlights the need to move beyond traditional markers of inflammation and adopt a multidimensional approach integrating clinical assessment, imaging, cognition, and biomarkers. Key Insights from the Lecture: Disease progression in MS can occur independently of relapses and may remain undetected using conventional inflammatory markers. Patients may continue to accumulate disability...

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