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Media Category: Progressive MS

The immunopathological hallmarks of neuromyelitis optica spectrum desorder (NMOSD)

Written by ParadigMS Foundation on .

Nikolaos Grigoriadis presents a keynote lecture on the pathophysiology of Neuromyelitis Optica Spectrum Disorder (NMOSD), focusing on the immunological mechanisms underlying disease activity. The session provides clinically relevant insights into how these mechanisms translate into relapse patterns and therapeutic targets. Key Insights from the Lecture: NMOSD is a relapse-driven disease, with disability primarily resulting from acute attacks rather than progressive mechanisms Anti-aquaporin-4 antibodies are present in the majority of patients and play a central pathogenic role...

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How to detect progression in Multiple Sclerosis

Written by ParadigMS Foundation on .

Celia Oreja-Guevara presented a clinically focused overview of how to detect disease progression in Multiple Sclerosis (MS). As therapeutic advances increasingly target progression, this keynote highlights the need to move beyond traditional markers of inflammation and adopt a multidimensional approach integrating clinical assessment, imaging, cognition, and biomarkers. Key Insights from the Lecture: Disease progression in MS can occur independently of relapses and may remain undetected using conventional inflammatory markers. Patients may continue to accumulate disability despite...

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The Role of Microglia in Multiple Sclerosis: Implications for Treatment with Bruton’s Tyrosine Kinase Inhibitors

Written by ParadigMS Foundation on .

Microglia are increasingly recognised as central regulators of neuroinflammation in Multiple Sclerosis (MS). Beyond their traditional classification, advances in molecular biology have revealed a spectrum of functional states that influence both tissue damage and repair. This lecture provides a concise overview of microglial biology in MS and explores how emerging therapeutic strategies, particularly Bruton tyrosine kinase (BTK) inhibitors, may modulate these cells to impact disease progression. Key Insights from the Lecture: Microglia as central orchestrators of CNS immunity: Microglia...

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Prognostic Factors for Evaluation of MS Therapy in Treatment Naive Patients

Written by ParadigMS Foundation on .

Magd Zakaria presented a clinically oriented approach to integrating prognostic factors into early treatment decision-making in Multiple Sclerosis (MS). Building on current evidence and international guidelines, this keynote addresses a central question in MS management: how to balance early use of high-efficacy therapies with individual disease activity, patient characteristics, and healthcare system constraints. Key Insights from the Lecture: Disability progression in MS is primarily driven by progression independent of relapse activity (PIRA), which begins early in the disease...

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Gregor Brecl Jakob : Optic Nerve Involvement in MS – Avoiding Misdiagnosis

Written by ParadigMS Foundation on .

In this short video interview, Gregor Brecl Jakob discusses the critical need for caution when attributing optic nerve pathology to multiple sclerosis. While optic nerve involvement is acknowledged in the diagnostic criteria, he emphasizes that optic neuritis has a broad differential diagnosis and should never be assumed to be MS-related without careful evaluation. Watch the interview Why is careful differential diagnosis essential when assessing optic nerve pathology in suspected multiple sclerosis? Gregor Brecl Jakob explains how specific clinical, imaging, and ophthalmological...

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Rodica Bălaşa: The Role of CSF Analysis in Multiple Sclerosis Diagnosis – Balancing Non-Invasive Tools and Biomarkers

Written by ParadigMS Foundation on .

In this short interview, Rodica Bălaşa discusses the evolving role of cerebrospinal fluid (CSF) analysis in the diagnosis of multiple sclerosis, particularly in light of the 2024 revision of the McDonald criteria. Although non-invasive investigations remain central to the diagnostic work-up, CSF continues to serve as an important complementary tool in selected patients. Rodica also addresses how advances in kappa free light chain testing have renewed interest in this established biomarker when additional diagnostic clarity is needed. Watch the interview When is cerebrospinal fluid...

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