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Media Category: Progressive MS

Detecting progression in Multiple Sclerosis: practical approaches and emerging tools

Written by ParadigMS Foundation on .

Progression in Multiple Sclerosis (MS) can begin early and may continue even in the absence of relapses or new MRI lesions. Detecting these changes sooner is becoming increasingly relevant as new therapeutic options for progression emerge. In this keynote, Celia Oreja-Guevara explores how progression can be identified in clinical practice through a combination of patient-reported changes, functional assessment, cognition, MRI, optical coherence tomography (OCT), fluid biomarkers and digital tools. Key Insights from the Lecture: Progression can occur from the early stages of Multiple...

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2024 McDonald Criteria: applying the new diagnostic framework in clinical practice

Written by ParadigMS Foundation on .

The 2024 revision of the McDonald Criteria introduces several important changes designed to support earlier and more accurate diagnosis of Multiple Sclerosis (MS). Mario Habek reviews how the revised criteria can be applied in clinical practice, including the incorporation of Radiologically Isolated Syndrome (RIS), the optic nerve as a fifth topography, kappa free light chains in cerebrospinal fluid analysis, and new MRI markers such as the central vein sign and paramagnetic rim lesions. Key Insights from the Lecture: Radiologically Isolated Syndrome can now meet diagnostic criteria...

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2024 McDonald Criteria: what changes for Multiple Sclerosis diagnosis?

Written by ParadigMS Foundation on .

The 2024 revisions of the McDonald Diagnostic Criteria introduce important changes designed to support earlier and more consistent diagnosis of Multiple Sclerosis (MS). Gregor Brecl Jakob explains the clinical rationale behind the revisions, including the incorporation of selected patients with Radiologically Isolated Syndrome (RIS), a unified diagnostic approach for relapsing and primary progressive MS, and the inclusion of the optic nerve as a fifth topography for demonstrating dissemination in space. Key Insights from the Lecture: The 2024 criteria move closer to a biologically...

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Patrick Vermersch: Detecting progression independent of relapse activity in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview In this interview, Patrick Vermersh discusses how clinicians can identify subtle progression through detailed patient questioning, multidimensional clinical assessment, advanced imaging and selected biomarkers. Key points discussed include: Why early detection of PIRA is important for anticipating further disability progression. The need to ask targeted questions about fatigue, walking, sensory symptoms, work, family life and daily activities. The limitations of relying on the Expanded Disability Status Scale (EDSS) alone. The value of assessing...

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Patrick Vermersch: Chronic Inflammation and PIRA in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview Progression independent of relapse activity (PIRA) is increasingly recognised as an important contributor to disability accumulation in Multiple Sclerosis (MS). In this interview, Patrick Vermersch explores the inflammatory mechanisms that may drive PIRA. He discusses the potential contributions of lymphocytes, microglia, astrocytes and other myeloid cells, as well as the challenges of evaluating chronic inflammation in vivo. Key points discussed include: The distinction between chronic inflammation associated with PIRA and focal inflammation associated...

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Long-term Efficacy and Safety of Anti-CD20 Therapies

Written by ParadigMS Foundation on .

Anti-CD20 therapies have transformed the treatment landscape of Multiple Sclerosis (MS), offering highly effective disease control through targeted B-cell depletion. As these therapies are increasingly used early in the disease course and maintained over many years, understanding their long-term efficacy, safety, and optimal use has become essential for clinical practice. In this webinar, Celia Oreja-Guevara and Patrick Vermersch review the latest evidence on anti-CD20 therapies, including ocrelizumab, ofatumumab, rituximab, and ublituximab. Drawing from pivotal clinical trials, extension...

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