Skip to main content

Media Category: x - Presentation (PPT)

Real-Life Experiences with biosimilars 

Written by ParadigMS Foundation on .

Key takeaways Generics and biosimilars are increasingly relevant in Multiple Sclerosis (MS) as healthcare systems seek cost containment without compromising clinical outcomes. Biosimilars are not identical copies, but are rigorously evaluated to demonstrate high similarity to reference biologics in structure, efficacy, safety, and immunogenicity through the EMA/FDA “totality of evidence” framework. Clinical trials and real-world evidence consistently show comparable efficacy and safety between originator biologics and biosimilars used in MS, including interferon beta, rituximab (off-label),...

Continue reading

ParadigMS Activity Report 2024 – 2025

Written by ParadigMS Foundation on .

ParadigMS Activity Summary 2024–2025 Advancing scientific knowledge through publications ParadigMS experts actively contributed to the international scientific literature, co-authoring multiple peer-reviewed publications addressing key clinical challenges. These included comprehensive reviews and position papers on topics such as the management of Multiple Sclerosis in older individuals, progressive MS, generics and biosimilars, and the evolving role of microglia and novel therapeutic targets. These publications reinforced ParadigMS’ commitment to translating scientific evidence...

Continue reading

ParadigMS Activity 2025 Booklet

Written by ParadigMS Foundation on .

Explore the full scope of ParadigMS Foundation’s expert-led activities with ParadigMS Activities 2025 Booklet —an at-a-glance guide to our live webinars, symposia, peer-reviewed publications, and EACCME®-accredited e-learning. Whether you’re looking for insightful discussions on B-cell therapies, updates on NMOSD, or practical tools for MS progression monitoring, this booklet offers a comprehensive overview of how ParadigMS supports neurologists across Europe, the Middle East, and North Africa.

Continue reading

Managing MS in Individuals Aged 55 and Above 

Written by ParadigMS Foundation on .

Key takeaways Aging and Disease Progression: MS in older adults often shifts from a relapsing to a progressive form, with compartmentalized inflammation and microglial activation playing a central role. Immunosenescence Considerations: Aging impacts immune function, increasing the risk of infections, especially with prolonged immunosuppressive therapy, necessitating a careful benefit-risk assessment in older patients. Treatment Efficacy Variability: Many DMTs show reduced efficacy in older MS patients, emphasizing the importance of individualized treatment plans based on age and disease...

Continue reading

Beyond EDSS: How to monitor disease progression in MS

Written by ParadigMS Foundation on .

Key takeaways Limitations of EDSS – The EDSS alone may not capture the full scope of MS progression, especially in cases where deterioration occurs independently of relapses (PIRA). Smoldering MS – MS can progress silently, with neurodegeneration happening beneath the surface, even when clinical symptoms seem stable. This requires a broader monitoring strategy. Multimodal Monitoring – Effective disease monitoring should go beyond neurological exams, integrating: Clinical assessments and patient-reported outcomes (PROs) Imaging techniques, such as MRI biomarkers and advanced neuroimaging Biomarkers...

Continue reading

FAQs

Is ParadigMS for free?

Yes, a ParadigMS subscription is free for healthcare practitioniers. 

Do subscriptions auto-renew?
Your subscription will automatically renew on yearly basis. If you cancel your plan, it will not renew at the end of your subscription cycle. 
I am a representative from industry, can I subscribe?

Free subscriptions to ParadigMS are reserved for healthcare practitioners. If you are a representative of the industry please contact us on learning@paradigms.foundation and we would advise you how to get the access to the material. 

What happens if I subscribe as a HCP if I am not?
If you subscribe as a healthcare practitioner and it is proven that you are not a healthcare practitioner, we will cancel your subscription immediately. 
I am a patient, can I subscribe?

ParadigMS is designed specifically for healthcare practitioners, with content and language tailored to their professional needs. While patients cannot subscribe directly, we encourage you to consult your healthcare provider for relevant insights and updates that may benefit you.

Why should I subscribe to ParadigMS's e-platform?

Subscribing to ParadigMS’s e-platform gives you access to up-to-date information and valuable learning materials on multiple sclerosis and NMO, along with expert insights and the latest innovations in the field. It’s an essential resource for staying informed and enhancing your knowledge in MS care.

How can I cancel my subscription?
You can cancel your subscription in your account settings. 
Can I financially support ParadigMS?

Yes, you can financially support ParadigMS! We welcome donations to help us continue our mission of advancing multiple sclerosis education and research. Your contribution directly supports the creation of educational resources, expert discussions, and innovative projects in MS care. Visit our donation page to learn more about how you can make a difference: ParadigMS Donate.