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Differential Diagnosis in MS, NMO-SD and MOGAD

Written by ParadigMS Foundation on .

ABSTRACT In the past 20 years, the concept of antibody mediated demyelinating disorders have emerged. These diseases, namely Aquaporin-4 (AQP4) positive neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte (MOG)- antibody associated disease (MOGAD), share common features with multiple sclerosis, but are fundamentally different in terms of pathophysiology, disease course and treatment. In this lecture we will provide a clinical, biological and imaging description of these two entities, and propose a focus on the features that helps to differentiate in between these...

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Dr. Matthijs Oyaert – Lecture on Antibodies in Focus Advancements in Diagnosing NMO and MOG-related CNS Disorders

Written by ParadigMS Foundation on .

ABSTRACT Over the last decade, knowledge of antibodies linked to inflammatory disorders of the central nervous system, including forms of neuromyelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis (ADEM), optic neuritis and transverse myelitis, has significantly reshaped the landscape of the diagnosis and clinical care. Notably, highly specific antibody assays have become an integral part of clinical decision making and include antibodies directed against the aquaporin-4 and anti–myelin oligodendrocyte glycoprotein (MOG).Various assays have been developed to...

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Cognition a marker for silent progression 2023

Written by ParadigMS Foundation on .

Cognitive impairment is a common marker of disease  progression and structural damage in strategic WM and GM regions explains cognitive impairment. AUTHOR CARLO POZZILLI Professor Pozzilli studied at the University of Rome “La Sapienza”. He then moved to the Hammersmith Hospital in London, UK, to take up a research post in 1980.In 1983, he became a Board Certified Neurologist at the University of Rome. In 1986 obtained a research grant in Neuroimaging at the Tohoku University, Sendai Japan.In 1987, he was awarded a PhD in Clinical Neurosciences by the University of Rome, where...

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Paediatric onset multiple sclerosis

Written by ParadigMS Foundation on .

BIOGRAPHY MELINDA MAGYARI Melinda Magyari is the director of The Danish Multiple Sclerosis Registry (link: www.dmsr.dk/) and a consultant neurologist at the Danish Multiple Sclerosis Center (COI). Her major research area is in multiple sclerosis and other inflammatory disorders of the central nervous system with a special interest in the changing epidemiology and gender differences. Using nationwide population-based data sources her research addresses questions on comorbidities, reproductive issues, risk factors and socioeconomic consequences in multiple sclerosis. She is involved...

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Precision Medicine in Multiple Sclerosis

Written by ParadigMS Foundation on .

Precision medicine represents the most advanced way that individual MS patients can be assessed and treated.  AUTHOR NIKOLAOS GRIGORIADISNikolaos Grigoriadis graduated from the Faculty of Medicine of the Aristotle University of Thessaloniki. He did his PhD thesis and residency in Neurology in the same institution. He has been specialized in clinical and experimental Neuroimmunology and CNS immunopathology in a number of research centers and institutions abroad. He is now Professor of Neurology at the Aristotle University of Thessaloniki and Head of the of the B’ Dept of Neurology, AHEPA...

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