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Media Category: Evolution of Disease

Immune reconstitution – Clinical aspects: available and future treatment

Written by ParadigMS Foundation on .

Immune reconstitution therapies are reshaping modern MS management, offering periods of lasting disease control without continuous immunosuppression. In this thought-provoking session, Prof. Patrick Vermersch, leading MS clinician and clinical trial expert, examines how IRTs work in real clinical practice, what drives long-term success, and how to navigate risks, patient selection, and treatment timing. Drawing on decades of research and clinical experience, Prof. Vermersch provides a clear and clinically meaningful framework for understanding cladribine, alemtuzumab, HSCT, and other...

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New insights in the 2024 McDonald criteria: imaging biomarkers shaping MS diagnosis

Written by ParadigMS Foundation on .

In this keynote lecture at the Belgian MS Symposium 2025, Pietro Maggi discussed how advanced MRI biomarkers have been integrated into the upcoming 2024 revisions of the McDonald diagnostic criteria for Multiple Sclerosis. Key Insights from the Webinar: These revisions aim to improve diagnostic precision and reduce misdiagnosis, particularly in early or atypical cases. Among the most significant updates are: Optic nerve involvement — now recognized as a fifth anatomical location for demonstrating dissemination in space (DIS), supported by MRI, visual evoked potentials (VEP), and optical...

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Translation of 2024 MS criteria for asymptomatic individuals into clinical practice: From RIS to MS

Written by ParadigMS Foundation on .

This recording will help you refine your MS diagnostic skills with Christine Lebrun-Frenay led-insights on the 2024 McDonald criteria and practical tools for confident early detection. Key Insights from the Webinar The 2024 McDonald revision refines diagnostic clarity in Multiple Sclerosis (MS) while maintaining strong continuity with the 2017 criteria. The update aims to support earlier, more confident diagnosis, particularly for asymptomatic or preclinical cases, and to reduce over-diagnosis in patients with vascular or migraine-related MRI findings. The session highlights how these...

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Smoldering disease

Written by ParadigMS Foundation on .

BIOGRAPHY CELIA OREJA-GUEVARA Vice Chair of Neurology and Head of Multiple Sclerosis Center at the University Hospital San Carlos, Madrid Professor Celia Oreja-Guevara is Vice Chair of Neurology and Head of Multiple Sclerosis Center at the University Hospital San Carlos, Madrid and Professor of Neurology at the University Complutense, Madrid, Spain. After receiving her MD from the University Complutense, Madrid, Professor Oreja-Guevara completed a PhD in neuroimmunology at the Max-Planck-Institute for Neurobiology, University of Munich, Munich (Germany). She then went on to complete...

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Patient-reported Outcomes: Novel Examination Techniques to Uncover Disability Accumulation

Written by ParadigMS Foundation on .

Identification of progression needs new (digital) tools: •Which can monitor different symptoma domains •Which can assessment neurological function in a quantitative way •Which are sensitive enough to detect even subtle changes Patient-reported outcomes can assist using innovative instruments to detect progression from the patient perspective. Data should be collected and analyzed on one platform.

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Cognition in MS

Written by ParadigMS Foundation on .

22th of March 2018, Third ParadigMS Symposium. The ParadigMS Foundation and the Belgian Study Group for Multiple Sclerosis (BSGMS) organised an interactive learning and networking experience. Here you can review one of the three lectures that were on the agenda: Cognition in MS ABSTRACTDr. Raed Alroughani discussed in his lecture the burden of cognitive impairment in MS. How to measure it and how to improve (or treat) cognitive impairment in MS. RAED ALROUGHANIDr. Raed Alroughani received his degree in medicine (MD) from Charles University. He underwent his neurology residency at the...

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