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Media Category: Evolution of Disease

CSF in the new diagnostic criteria in multiple sclerosis

Written by ParadigMS Foundation on .

The diagnosis of multiple sclerosis (MS) has significantly evolved over time, moving from a purely clinical approach to a more integrated model combining imaging and biological markers. Among these, cerebrospinal fluid (CSF) analysis has regained a central role. Recent advances, particularly the use of kappa free light chains (KFLC), are transforming diagnostic practices by offering a faster, more accessible, and reliable alternative to traditional methods. Key Insights from the Lecture: CSF has long been essential in MS diagnosis Diagnostic criteria have evolved significantly MRI...

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The immunopathological hallmarks of neuromyelitis optica spectrum desorder (NMOSD)

Written by ParadigMS Foundation on .

Nikolaos Grigoriadis presents a keynote lecture on the pathophysiology of Neuromyelitis Optica Spectrum Disorder (NMOSD), focusing on the immunological mechanisms underlying disease activity. The session provides clinically relevant insights into how these mechanisms translate into relapse patterns and therapeutic targets. Key Insights from the Lecture: NMOSD is a relapse-driven disease, with disability primarily resulting from acute attacks rather than progressive mechanisms Anti-aquaporin-4 antibodies are present in the majority of patients and play a central pathogenic role...

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How to detect progression in Multiple Sclerosis

Written by ParadigMS Foundation on .

Celia Oreja-Guevara presented a clinically focused overview of how to detect disease progression in Multiple Sclerosis (MS). As therapeutic advances increasingly target progression, this keynote highlights the need to move beyond traditional markers of inflammation and adopt a multidimensional approach integrating clinical assessment, imaging, cognition, and biomarkers. Key Insights from the Lecture: Disease progression in MS can occur independently of relapses and may remain undetected using conventional inflammatory markers. Patients may continue to accumulate disability despite...

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Rodica Bălaşa: The Role of CSF Analysis in Multiple Sclerosis Diagnosis – Balancing Non-Invasive Tools and Biomarkers

Written by ParadigMS Foundation on .

In this short interview, Rodica Bălaşa discusses the evolving role of cerebrospinal fluid (CSF) analysis in the diagnosis of multiple sclerosis, particularly in light of the 2024 revision of the McDonald criteria. Although non-invasive investigations remain central to the diagnostic work-up, CSF continues to serve as an important complementary tool in selected patients. Rodica also addresses how advances in kappa free light chain testing have renewed interest in this established biomarker when additional diagnostic clarity is needed. Watch the interview When is cerebrospinal fluid...

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Rodica Bălaşa: Kappa Free Light Chains – A Practical, Objective Tool in CSF Analysis for MS

Written by ParadigMS Foundation on .

In this short interview, Rodica Bălaşa discusses how cerebrospinal fluid analysis in multiple sclerosis has evolved with the introduction of the kappa free light chain index. Watch the interview How have kappa free light chains improved cerebrospinal fluid evaluation in multiple sclerosis? In the interview, Rodica Bălaşa explains how cerebrospinal fluid evaluation in multiple sclerosis has evolved from a labor-intensive, subjective process to a more practical, quantitative, and cost-effective approach using kappa free light chains. Key points discussed include: The evolution...

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Rodica Bălaşa on Cerebrospinal Fluid as a diagnostic window in Multiple Sclerosis

Written by ParadigMS Foundation on .

Why does cerebrospinal fluid (CSF) remain an important tool in the diagnosis of multiple sclerosis, even with advances in imaging? Watch the interview In the interview, Rodica Bălaşa explains the ongoing importance of cerebrospinal fluid (CSF) evaluation in multiple sclerosis, emphasizing its role as a window into the brain’s pathological processes. Key points discussed include: The evolving role of CSF analysis in the diagnosis of multiple sclerosis Why CSF remains relevant despite advances in imaging and other non-invasive tools Its position within the 2024 McDonald criteria When...

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