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Media Category: Evolution of Disease

Radiologically Isolated Syndrome: from incidental findings to preclinical Multiple Sclerosis

Written by ParadigMS Foundation on .

Radiologically Isolated Syndrome (RIS) is becoming increasingly relevant as Multiple Sclerosis (MS) diagnosis moves from a purely clinical model toward a more biologically informed framework. In this keynote, Cecilia Rajda explores how the 2024 diagnostic criteria are reshaping the definition of RIS, which patients may now fulfil criteria for MS, and what this means for diagnostic work-up, follow-up, treatment decisions and communication with patients. Key Insights from the Lecture: Multiple Sclerosis may begin biologically before the first clinical symptoms appear. RIS describes...

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Detecting progression in Multiple Sclerosis: practical approaches and emerging tools

Written by ParadigMS Foundation on .

Progression in Multiple Sclerosis (MS) can begin early and may continue even in the absence of relapses or new MRI lesions. Detecting these changes sooner is becoming increasingly relevant as new therapeutic options for progression emerge. In this keynote, Celia Oreja-Guevara explores how progression can be identified in clinical practice through a combination of patient-reported changes, functional assessment, cognition, MRI, optical coherence tomography (OCT), fluid biomarkers and digital tools. Key Insights from the Lecture: Progression can occur from the early stages of Multiple...

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Patrick Vermersch: Detecting progression independent of relapse activity in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview In this interview, Patrick Vermersh discusses how clinicians can identify subtle progression through detailed patient questioning, multidimensional clinical assessment, advanced imaging and selected biomarkers. Key points discussed include: Why early detection of PIRA is important for anticipating further disability progression. The need to ask targeted questions about fatigue, walking, sensory symptoms, work, family life and daily activities. The limitations of relying on the Expanded Disability Status Scale (EDSS) alone. The value of assessing...

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Patrick Vermersch: Chronic Inflammation and PIRA in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview Progression independent of relapse activity (PIRA) is increasingly recognised as an important contributor to disability accumulation in Multiple Sclerosis (MS). In this interview, Patrick Vermersch explores the inflammatory mechanisms that may drive PIRA. He discusses the potential contributions of lymphocytes, microglia, astrocytes and other myeloid cells, as well as the challenges of evaluating chronic inflammation in vivo. Key points discussed include: The distinction between chronic inflammation associated with PIRA and focal inflammation associated...

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Long-term Efficacy and Safety of Anti-CD20 Therapies

Written by ParadigMS Foundation on .

Anti-CD20 therapies have transformed the treatment landscape of Multiple Sclerosis (MS), offering highly effective disease control through targeted B-cell depletion. As these therapies are increasingly used early in the disease course and maintained over many years, understanding their long-term efficacy, safety, and optimal use has become essential for clinical practice. In this webinar, Celia Oreja-Guevara and Patrick Vermersch review the latest evidence on anti-CD20 therapies, including ocrelizumab, ofatumumab, rituximab, and ublituximab. Drawing from pivotal clinical trials, extension...

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CSF in the new diagnostic criteria in multiple sclerosis

Written by ParadigMS Foundation on .

The diagnosis of multiple sclerosis (MS) has significantly evolved over time, moving from a purely clinical approach to a more integrated model combining imaging and biological markers. Among these, cerebrospinal fluid (CSF) analysis has regained a central role. Recent advances, particularly the use of kappa free light chains (KFLC), are transforming diagnostic practices by offering a faster, more accessible, and reliable alternative to traditional methods. Key Insights from the Lecture: CSF has long been essential in MS diagnosis Diagnostic criteria have evolved significantly MRI...

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