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MRI and the implication of the new diagnostic criteria (certified by ParadigMS)

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About this e-learning

Welcome! This e-learning course explores the evolving role of magnetic resonance imaging (MRI) in the diagnosis of Multiple Sclerosis (MS), in light of the 2024 revision of the diagnostic criteria. With a strong focus on clinical applicability, the course translates recent scientific advances into practical guidance for everyday diagnostic decision-making.

Through expert-led presentations, the module reviews the rationale behind the updated diagnostic framework and examines how conventional MRI findings and novel imaging biomarkers, such as the Central Vein Sign and Paramagnetic Rim Lesions, contribute to improved diagnostic accuracy. Particular attention is given to the integration of the optic nerve as a fifth topography, as well as to challenging clinical scenarios including Radiologically Isolated Syndrome, older patients, and differential diagnosis.

This course provides neurologists and related healthcare professionals with evidence-based insights and practical tools to apply the 2024 MS diagnostic criteria with confidence, supporting accurate diagnosis while minimizing the risk of misdiagnosis.

Certificate

Please note that this webinar is currently being submitted by ParadigMS to the European Accreditation Council for Continuing Medical Education (EACCME®) for CME accreditation.

While the EACCME accreditation process is ongoing, participants who complete the e-learning will receive a ParadigMS Certificate of Participation.

Once the accreditation is validated, participants will gain an EACCME Certificate upon completion.

Once you confirmed you participated, you will be able to download your Certificate of Participation from ‘Your Account‘.

How to confirm your participation: complete this e-learning course (it includes one section, one satisfaction survey and one exam).

Learning objectives

Celia Oreja-Guevara – MRI and Dissemination in Space in the 2024 MS Diagnostic Criteria

This presentation focuses on the role of conventional and advanced MRI in the updated Dissemination in Space (DIS) criteria introduced in the 2024 revision of the MS diagnostic framework. It reviews the rationale for including the optic nerve as a fifth topography and discusses how MRI findings contribute to diagnostic confidence in patients with clinically isolated syndromes and early disease presentations.

Learning Objectives:

  • Review the evolution of MRI-based diagnostic criteria from McDonald 2017 to the 2024 revision.
  • Understand the updated DIS framework, including the optic nerve as a fifth anatomical location.
  • Identify MRI features that support DIS in different clinical scenarios.
  • Recognize situations in which additional MRI evidence is recommended, including older patients and those with vascular comorbidities.
  • Apply DIS criteria appropriately to improve diagnostic accuracy while reducing the risk of misdiagnosis.

Cristina Granziera – Novel MRI biomarkers in the 2024 MS diagnostic criteria

This presentation addresses the contribution of novel MRI biomarkers, specifically the Central Vein Sign (CVS) and Paramagnetic Rim Lesions (PRL), to the 2024 revision of the MS diagnostic criteria. It reviews their pathological basis, imaging characteristics, and clinical relevance, with a focus on differential diagnosis and diagnostic specificity.

Learning Objectives:

  • Understand the pathophysiological and radiological basis of the Central Vein Sign and Paramagnetic Rim Lesions.
  • Describe validated thresholds and simplified rules for the use of CVS in clinical practice.
  • Assess the diagnostic value of PRL in distinguishing MS from mimics.
  • Discuss the role of advanced MRI biomarkers in Radiologically Isolated Syndrome and early MS.
  • Integrate CVS and PRL into a structured, evidence-based diagnostic approach.

The course includes a dedicated Q&A session, during which faculty address clinically relevant questions and further elaborate on key concepts discussed throughout the presentations, supporting knowledge translation into daily practice.

This content is funded with ParadigMS own funds.

Course Content

FAQs

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Yes, a ParadigMS subscription is free for healthcare practitioniers. 

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Why should I subscribe to ParadigMS's e-platform?

Subscribing to ParadigMS’s e-platform gives you access to up-to-date information and valuable learning materials on multiple sclerosis and NMO, along with expert insights and the latest innovations in the field. It’s an essential resource for staying informed and enhancing your knowledge in MS care.

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Yes, you can financially support ParadigMS! We welcome donations to help us continue our mission of advancing multiple sclerosis education and research. Your contribution directly supports the creation of educational resources, expert discussions, and innovative projects in MS care. Visit our donation page to learn more about how you can make a difference: ParadigMS Donate.