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New Video Interview: Gregor Brecl‑Jakob on Optic Nerve Involvement as a Core Topography in MS

ParadigMS Foundation

By ParadigMS Foundation

October 06, 2026

We’re pleased to share a new video interview featuring Gregor Brecl‑Jakob, in which he discusses the increasing recognition of optic nerve involvement as a core topographical feature in Multiple Sclerosis (MS). In this video, Brecl‑Jakob explains why formally acknowledging the optic nerve as a typical anatomical site enhances diagnostic sensitivity and better reflects disease dissemination observed in clinical practice, supporting neurologists in earlier and more confident diagnosis.

Highlights of the interview include:

  • The importance of considering the optic nerve as a formally recognized topographical location in MS diagnosis
  • Why optic neuritis should carry the same diagnostic weight as brain or spinal cord lesions
  • How multimodal tools such as optical coherence tomography (OCT), MRI, and visual evoked potentials (VEPs) enhance detection of optic nerve involvement
  • The impact of this inclusion on supporting earlier and more confident clinical decision‑making

This video reflects ParadigMS’ ongoing commitment to clinically relevant, expert-led education that informs everyday decision-making in MS care.

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