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Media Category: Prognosis

Central vein sign and paramagnetic rim lesions in Multiple Sclerosis diagnosis

Written by ParadigMS Foundation on .

New MRI biomarkers are becoming increasingly relevant in the diagnosis of Multiple Sclerosis (MS). Among them, the central vein sign (CVS) and paramagnetic rim lesions (PRLs) can improve diagnostic specificity and help distinguish MS from conditions that may mimic the disease. Šarlota Mesaroš reviews the biological basis, MRI detection and clinical relevance of these two biomarkers, and explains how they are incorporated into the revised McDonald diagnostic criteria. Key Insights from the Lecture: The central vein sign reflects a characteristic pathobiological feature of Multiple...

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Radiologically Isolated Syndrome: from incidental findings to preclinical Multiple Sclerosis

Written by ParadigMS Foundation on .

Radiologically Isolated Syndrome (RIS) is becoming increasingly relevant as Multiple Sclerosis (MS) diagnosis moves from a purely clinical model toward a more biologically informed framework. In this keynote, Cecilia Rajda explores how the 2024 diagnostic criteria are reshaping the definition of RIS, which patients may now fulfil criteria for MS, and what this means for diagnostic work-up, follow-up, treatment decisions and communication with patients. Key Insights from the Lecture: Multiple Sclerosis may begin biologically before the first clinical symptoms appear. RIS describes...

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Detecting progression in Multiple Sclerosis: practical approaches and emerging tools

Written by ParadigMS Foundation on .

Progression in Multiple Sclerosis (MS) can begin early and may continue even in the absence of relapses or new MRI lesions. Detecting these changes sooner is becoming increasingly relevant as new therapeutic options for progression emerge. In this keynote, Celia Oreja-Guevara explores how progression can be identified in clinical practice through a combination of patient-reported changes, functional assessment, cognition, MRI, optical coherence tomography (OCT), fluid biomarkers and digital tools. Key Insights from the Lecture: Progression can occur from the early stages of Multiple...

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Magd Zakaria: Recognising Typical and Atypical Presentations in Multiple Sclerosis

Written by ParadigMS Foundation on .

Watch the interview Magd Zakaria discusses the clinical features that can help distinguish typical presentations of Multiple Sclerosis from red flags suggestive of alternative demyelinating disorders. Visual, spinal cord and brainstem syndromes are among the most common clinical presentations at the onset of Multiple Sclerosis (MS), often occurring as a clinically isolated syndrome (CIS). In this interview, Magd Zakaria reviews the characteristic features of these presentations and highlights findings that are atypical for MS. He explains how symptom severity, bilateral involvement,...

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Magd Zakaria: Prognostic Factors in Multiple Sclerosis: Supporting Early Treatment Decisions

Written by ParadigMS Foundation on .

Watch the interview Selecting the most appropriate treatment at diagnosis requires an accurate assessment of disease activity and prognosis. In this interview, Magd Zakaria discusses a practical scoring system that combines demographic, clinical and MRI characteristics to help stratify treatment-naïve patients according to their risk of disease progression and support informed therapeutic decisions. Key points discussed include: Why prognostic assessment remains essential when selecting an initial treatment strategy. The development of a practical scoring system based...

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Prognostic Factors for Evaluation of MS Therapy in Treatment Naive Patients

Written by ParadigMS Foundation on .

Magd Zakaria presented a clinically oriented approach to integrating prognostic factors into early treatment decision-making in Multiple Sclerosis (MS). Building on current evidence and international guidelines, this keynote addresses a central question in MS management: how to balance early use of high-efficacy therapies with individual disease activity, patient characteristics, and healthcare system constraints. Key Insights from the Lecture: Disability progression in MS is primarily driven by progression independent of relapse activity (PIRA), which begins early in the disease...

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