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Media Category: Precision medicine

The Role of Microglia in Multiple Sclerosis: Implications for Treatment with Bruton’s Tyrosine Kinase Inhibitors

Written by ParadigMS Foundation on .

Microglia are increasingly recognised as central regulators of neuroinflammation in Multiple Sclerosis (MS). Beyond their traditional classification, advances in molecular biology have revealed a spectrum of functional states that influence both tissue damage and repair. This lecture provides a concise overview of microglial biology in MS and explores how emerging therapeutic strategies, particularly Bruton tyrosine kinase (BTK) inhibitors, may modulate these cells to impact disease progression. Key Insights from the Lecture: Microglia as central orchestrators of CNS immunity: Microglia...

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Rodica Bălaşa: The Role of CSF Analysis in Multiple Sclerosis Diagnosis – Balancing Non-Invasive Tools and Biomarkers

Written by ParadigMS Foundation on .

In this short interview, Rodica Bălaşa discusses the evolving role of cerebrospinal fluid (CSF) analysis in the diagnosis of multiple sclerosis, particularly in light of the 2024 revision of the McDonald criteria. Although non-invasive investigations remain central to the diagnostic work-up, CSF continues to serve as an important complementary tool in selected patients. Rodica also addresses how advances in kappa free light chain testing have renewed interest in this established biomarker when additional diagnostic clarity is needed. Watch the interview When is cerebrospinal fluid...

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Rodica Bălaşa: Kappa Free Light Chains – A Practical, Objective Tool in CSF Analysis for MS

Written by ParadigMS Foundation on .

In this short interview, Rodica Bălaşa discusses how cerebrospinal fluid analysis in multiple sclerosis has evolved with the introduction of the kappa free light chain index. Watch the interview How have kappa free light chains improved cerebrospinal fluid evaluation in multiple sclerosis? In the interview, Rodica Bălaşa explains how cerebrospinal fluid evaluation in multiple sclerosis has evolved from a labor-intensive, subjective process to a more practical, quantitative, and cost-effective approach using kappa free light chains. Key points discussed include: The evolution...

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Rodica Bălaşa on Cerebrospinal Fluid as a diagnostic window in Multiple Sclerosis

Written by ParadigMS Foundation on .

Why does cerebrospinal fluid (CSF) remain an important tool in the diagnosis of multiple sclerosis, even with advances in imaging? Watch the interview In the interview, Rodica Bălaşa explains the ongoing importance of cerebrospinal fluid (CSF) evaluation in multiple sclerosis, emphasizing its role as a window into the brain’s pathological processes. Key points discussed include: The evolving role of CSF analysis in the diagnosis of multiple sclerosis Why CSF remains relevant despite advances in imaging and other non-invasive tools Its position within the 2024 McDonald criteria When...

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Sphingosine system – Clinical aspects: available and future treatment

Written by ParadigMS Foundation on .

This lecture reviews the clinical use of sphingosine-1-phosphate (S1P) receptor modulators in Multiple Sclerosis, with a focus on their mechanisms of action, receptor selectivity, pharmacokinetics, and safety considerations. Magd Zakaria discusses how differences in half-life, metabolism, and receptor targeting influence efficacy, adverse events, monitoring requirements, and treatment sequencing, including switching strategies and special populations such as women planning pregnancy. Key Insights from the Lecture: S1P receptor modulators exert their therapeutic effect by modulating...

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