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Media Category: Pathology

NMOSD Panel Discussion: Pathophysiology, Monitoring, and Treatment Challenges

Written by ParadigMS Foundation on .

This expert panel discussion explores the current challenges in understanding and managing neuromyelitis optica spectrum disorder (NMOSD). Bringing together clinical perspectives, the conversation highlights gaps in pathophysiology, limitations in monitoring tools, and ongoing uncertainties in long-term treatment strategies. Despite advances in biomarkers and therapies, real-world decision-making remains largely driven by clinical experience. Key Insights from the Lecture: Antibodies alone are not sufficient to cause disease Clinical context remains essential T cells play a...

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CSF in the new diagnostic criteria in multiple sclerosis

Written by ParadigMS Foundation on .

The diagnosis of multiple sclerosis (MS) has significantly evolved over time, moving from a purely clinical approach to a more integrated model combining imaging and biological markers. Among these, cerebrospinal fluid (CSF) analysis has regained a central role. Recent advances, particularly the use of kappa free light chains (KFLC), are transforming diagnostic practices by offering a faster, more accessible, and reliable alternative to traditional methods. Key Insights from the Lecture: CSF has long been essential in MS diagnosis Diagnostic criteria have evolved significantly MRI...

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The immunopathological hallmarks of neuromyelitis optica spectrum desorder (NMOSD)

Written by ParadigMS Foundation on .

Nikolaos Grigoriadis presents a keynote lecture on the pathophysiology of Neuromyelitis Optica Spectrum Disorder (NMOSD), focusing on the immunological mechanisms underlying disease activity. The session provides clinically relevant insights into how these mechanisms translate into relapse patterns and therapeutic targets. Key Insights from the Lecture: NMOSD is a relapse-driven disease, with disability primarily resulting from acute attacks rather than progressive mechanisms Anti-aquaporin-4 antibodies are present in the majority of patients and play a central pathogenic role...

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Gregor Brecl Jakob : Optic Nerve Involvement in MS – Avoiding Misdiagnosis

Written by ParadigMS Foundation on .

In this short video interview, Gregor Brecl Jakob discusses the critical need for caution when attributing optic nerve pathology to multiple sclerosis. While optic nerve involvement is acknowledged in the diagnostic criteria, he emphasizes that optic neuritis has a broad differential diagnosis and should never be assumed to be MS-related without careful evaluation. Watch the interview Why is careful differential diagnosis essential when assessing optic nerve pathology in suspected multiple sclerosis? Gregor Brecl Jakob explains how specific clinical, imaging, and ophthalmological...

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Šarlota Mesaroš on paramagnetic rim lesions specific for multiple sclerosis

Written by ParadigMS Foundation on .

In this short interview, Šarlota Mesaroš discusses the clinical relevance of paramagnetic rim lesions and their growing role in the diagnostic evaluation of multiple sclerosis. Watch the interview What is the clinical value of paramagnetic rim lesions in multiple sclerosis? Šarlota Mesaroš presents a clear, practice-based overview of paramagnetic rim lesions and their relevance in the diagnosis of multiple sclerosis, drawing directly on advances in MRI imaging and current diagnostic criteria. Key points discussed include: What paramagnetic rim lesions are and why they reflect...

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Jelena Drulović on the power of interactive education in advancing MS care

Written by ParadigMS Foundation on .

In this short interview, Jelena Drulović reflects on the value of interactive, discussion-based education in multiple sclerosis care. Watch the interview Why is interactive, discussion-based education essential for improving multiple sclerosis care? Jelena Drulović explains how active engagement between experts and clinicians enhances knowledge transfer and translates scientific discussion into better clinical practice. Key points discussed include: Why interactive, discussion-based education strengthens MS care The value of direct exchange between experts and practicing...

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