Media Category: Microglia

Microglia are increasingly recognised as central regulators of neuroinflammation in Multiple Sclerosis (MS). Beyond their traditional classification, advances in molecular biology have revealed a spectrum of functional states that influence both tissue damage and repair. This lecture provides a concise overview of microglial biology in MS and explores how emerging therapeutic strategies, particularly Bruton tyrosine kinase (BTK) inhibitors, may modulate these cells to impact disease progression. Key Insights from the Lecture: Microglia as central orchestrators of CNS immunity:...

In this keynote from Athens, Professor Laura Airas presents the central role of microglia in multiple sclerosis pathology and progression, with a focus on how these cells can both protect and damage the CNS. The presentation reviews microglial biology, their contribution to smouldering MS lesions, and how advanced imaging, especially TSPO-PET, can visualise microglial activation in vivo. Emerging therapeutic strategies, including BTK inhibitors and repurposed agents, are discussed as potential ways to modulate microglia and slow progression. Key Insights from the Lecture: ...