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Media Category: Microglia

The immunopathological hallmarks of neuromyelitis optica spectrum desorder (NMOSD)

Written by ParadigMS Foundation on .

Nikolaos Grigoriadis presents a keynote lecture on the pathophysiology of Neuromyelitis Optica Spectrum Disorder (NMOSD), focusing on the immunological mechanisms underlying disease activity. The session provides clinically relevant insights into how these mechanisms translate into relapse patterns and therapeutic targets. Key Insights from the Lecture: NMOSD is a relapse-driven disease, with disability primarily resulting from acute attacks rather than progressive mechanisms Anti-aquaporin-4 antibodies are present in the majority of patients and play a central pathogenic role...

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Sphingosine system – pathology and pathway

Written by ParadigMS Foundation on .

This lecture introduces the sphingosine-1-phosphate (S1P) system as a complex, tightly regulated lipid-signaling pathway with relevance beyond Multiple Sclerosis, extending into vascular biology and other neurological diseases. The speaker explains how S1P is produced and transported, how it acts both intracellularly and via surface receptors, and why its biological effects depend on compartment, binding proteins, and the balance between pro-apoptotic ceramide and pro-survival S1P. The talk also links S1P dysregulation to disease mechanisms and emerging research questions, including...

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Endocannabinoid system – pathology and pathway

Written by ParadigMS Foundation on .

The endocannabinoid system represents a complex and independent neurotransmitter system with a central role in maintaining homeostasis within the nervous and immune systems. In this lecture, Nikolaos Grigoriadis reviewed the biological foundations of the endocannabinoid system, its mechanisms of action in the central nervous system and immune response, and the growing experimental and clinical evidence supporting its neuroprotective and immunomodulatory functions, with particular relevance for Multiple Sclerosis and other neuroinflammatory conditions. Key Insights from the Lecture: The...

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Microglia: pathology and pathway

Written by ParadigMS Foundation on .

In this keynote from Athens, Professor Laura Airas presents the central role of microglia in multiple sclerosis pathology and progression, with a focus on how these cells can both protect and damage the CNS. The presentation reviews microglial biology, their contribution to smouldering MS lesions, and how advanced imaging, especially TSPO-PET, can visualise microglial activation in vivo. Emerging therapeutic strategies, including BTK inhibitors and repurposed agents, are discussed as potential ways to modulate microglia and slow progression. Key Insights from the Lecture: Microglia...

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Microglia – Clinical aspects: available and future treatment

Written by ParadigMS Foundation on .

In this educational session, Prof. Celia Oreja-Guevara explores the crucial role of microglia in multiple sclerosis and how our evolving understanding of these resident immune cells is reshaping approaches to disease monitoring and treatment. Professor Oreja-Guevara discusses how microglial activation contributes to lesion development, chronic inflammation, and disability progression, while highlighting emerging therapeutic strategies targeting neuroinflammation. With clear clinical relevance and a forward-looking perspective, this presentation is ideal for neurologists and clinicians interested...

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Prof. Patrick Vermersch on Microglia in Multiple Sclerosis

Written by ParadigMS Foundation on .

“Why are microglia important in the treatment of Multiple Sclerosis?” * Please note that all the captions were generated automatically. If they do not appear, click on CC in the navigation. Interested in the next interview question? “Are there any multiple sclerosis drug therapies that target microglia?” Log-in or subscribe. Curious to learn more about the expert behind this interview? Visit Patrick Vermersch’s full biography for more insights into his expertise. Meet the Expert

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