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Journal Article: Managing multiple sclerosis in individuals aged 55 and above: a comprehensive review

ParadigMS Foundation

By ParadigMS Foundation

June 12, 2024

The article ‘Managing multiple sclerosis in individuals aged 55 and above: a comprehensive review’ was published as open access in the Frontiers Media on the 5th of April 2024.

Authors: Óscar Fernández*¥1,2, Per Soelberg Sörensen3,4, Giancarlo Comi5,6, Patrick Vermersch7, Hans-Peter Hartung8,9,10, Letizia Leocan5,6, Thomas Berger11,12, Bart Van Wijmeersch13,14, Celia Oreja-Guevara¥15,16

1Departament of Pharmacology, Faculty of Medicine; Institute of Biomedical Research of Malaga (IBIMA), Regional University Hospital of Malaga, Malaga, Spain. 2Department of Pharmacology and Pediatry, Faculty of Medicine, University of Malaga, Malaga, Spain. 3Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 4Copenhagen and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 5Department of Neurorehabilitation Sciences, Multiple Sclerosis Centre Casa di Cura Igea, Milan, Italy. 6University Vita-Salute San Raffaele, Milan, Italy. 7Univ. Lille, Inserm U1172 LilNCog, CHU Lille, FHU Precise, Lille, France. 8Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. 9Brain and Mind Center, University of Sydney, Sydney, NSW, Australia. 10Department of Neurology, Palacky University Olomouc, Olomouc, Czechia. 11Department of Neurology, Medical University of Vienna, Vienna, Austria. 12Comprehensive Center for Clinical Neurosciences & Mental Health, Medical University of Vienna, Vienna, Austria. 13University MS Centre, Hasselt-Pelt, Belgium. 14Rehabilitation and Multiple Sclerosis (MS), Noorderhart Hospitals, Pelt, Belgium. 15Department of Neurology, Hospital Clínico Universitario San Carlos, IdISSC, Madrid, Spain. 16Department of Medicine, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain.

 ¥ Both authors contributed equally to this work


New Review Sheds Light on Managing Multiple Sclerosis in Older Adults

Managing Multiple Sclerosis (MS) in individuals aged 55 and above is becoming increasingly complex, according to a comprehensive new review. The study highlights the unique challenges posed by the interaction of aging, comorbidities, immunosenescence, and MS pathophysiology.

Key Findings:

  • Rising Incidence: There is a notable increase in MS cases among older adults, with a shift from relapsing-remitting to progressive disease forms.
  • Multimorbidity and Polypharmacy: Many older MS patients face additional health conditions and are on multiple medications, complicating their treatment.

Therapeutic Insights:

  • Disease-Modifying Treatments (DMTs): The review evaluates the efficacy and safety of current therapies for older patients. Emerging treatments, including Bruton tyrosine kinase (BTK) inhibitors and drugs targeting remyelination and neuroprotection, show promise.
  • Critical Decisions: The study underscores the importance of careful decision-making regarding the initiation, de-escalation, and discontinuation of DMTs.

Holistic Care Approaches:

  • Non-Pharmacologic Treatments: Physical therapy, neuromodulation, cognitive rehabilitation, and psychotherapy play crucial roles in comprehensive care.
  • MS Care Units and Advance Care Planning: These are essential for providing patient-centric care and ensuring treatments align with patient preferences.

The review also calls for more personalized management and continuous monitoring of MS patients. It advocates for inclusive clinical trial designs that represent a wider age range to enhance treatment strategies for this growing demographic.

© 2024 Frontiers Media S.A. All rights reserved.


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