By ParadigMS Foundation
The term ‘Smouldering MS’ is one of the latest concepts that MS researchers are advancing in an attempt to understand and address ongoing clinical deterioration in multiple sclerosis patients despite an apparent absence of focal inflammatory activity (relapse and/or MRI activity).
In a recent review article co-authored by ParadigMS board members Professors Veronica Popescu and Laura Airas, Giovannoni et al. (2022) outline what they believe is driving the pathology underlying smouldering MS. They suggest that current disease-modifying therapies do not adequately treat and manage smouldering MS, and provide insights into what needs to be done to detect and eventually reverse this ongoing neurodegeneration in the brains of MS patients that eventually leads to disability progression.
You can read this paper, which can be downloaded freely from PubMed.
If you are interested in this topic, Professor Giovannoni also provides an interesting lecture that can be viewed on YouTube.