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E-Learning: Part 5/5 on Microglia: Role of microglia in neuroprotection and remyelination processes in MS (Accredited by EACCME)

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Introduction

Microglia are a class of innate immune cells in the central nervous system (CNS). In the space of just a few years they have become a major focus of attention in multiple sclerosis (MS) research and as a therapeutic target to prevent disability progression in persons with MS.

This e-learning module is part of a series of 5 e-learning modules created by ParadigMS on ‘the role of Microglia in Multiple Sclerosis’. Each module has a lead author and several contributors, all are neurologists with an expertise in multiple sclerosis and members of ParadigMS.

You will receive an EACCME certificate and 0,5 European CME credit (ECMEC®) upon completing the e-learning and successfully passing the exam. Should you not be able to download the certificate, or need any further information, please contact: learning@paradigms.foundation

This self paced e-learning covers ‘neuroprotection and remyelination processes in MS’ in the context of Microglia.

About this module

In this e-Learning section, ParadigMS Expert and highly respected MS neurologist Prof. Nikolaos Grigoriadis provides an overview of remyelination and how this process is a key mechanism to providing neuroprotection during MS.

Normally functioning microglia regulate remyelination through several mechanisms, such as phagocytosis of myelin debris following a demyelinating episode. However, in the MS brain, the aberrant activation of microglia at the site of a brain lesion may be inhibitory to the recruitment of oligodendrocyte precursor cells (OPCs) to the site and their differentiation into mature oligodendrocytes, the cells that form myelin. Moreover, the absence of chemoattractants and growth factors secreted by normally functioning microglia to support the recruitment, proliferation, and differentiation of OPCs to create a supportive environment for remyelination is likely to be detrimental to the brain’s capacity to recover from neurodegenerative damage.

As most currently available disease-modifying therapies are not brain-penetrant, they are unlikely to have any significant effect on the remyelinating process. Future classes DMTs aiming to modulate microglial responses may facilitate remyelination, and thereby provide neuroprotection as well as reduce disability progression due to ongoing neurodegeneration.

By the end of this e-learning module, participants will:


• Understand why remyelination is considered a key mechanism to provide neuroprotection during MS;

• Understand the mechanisms through which microglia regulates remyelination;

• Understand current and future DMTs’ effects on the remyelinating process to provide neuroprotection.

Educational slide decks
endorsed by experts

Minimum two MS experts collaborate to produce an educational slide deck. These slide decks are presented (live) to ParadigMS members, peer reviewed and updated.
The slide decks are published on the ParadigMS website “on behalf of ParadigMS”.

Consensus publications

Based on the slide decks, publications are produced. These publications are peer reviewed and published as consensus publications.

Regional and national educational events

Regional (fe: Scandinavian countries, Benelux, …) or national events where state-of-the-art science is transferred to general neurologists and other care givers (nurses, etc) that are confronted with MS in their day to day practice.

Web-based educational tools and resources

Webinars can complement the educational events.

Medical education (ME) programs

The educational slide decks, events and webinars can be important building blocks of accredited educational programs.

FAQs

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Your subscription will automatically renew on a monthly or yearly basis, depending on the plan you have chosen. If you cancel your plan, it will not renew at the end of your subscription cycle. It will end once the period you have paid for is over.
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If you subscribe as a healthcare practitioner and it is proven that you are not a healthcare practitioner, you will be banned immediately from the community and could be liable to prosecution.
How can I cancel my trial or subscription?
You can cancel your trial or subscription in your account settings. If you cancel during the trial period you will not be charged.

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