Skip to main content

E-Learning: How to Uncover Subtle Progression in Multiple Sclerosis (Certified by ParadigMS)

Current Status
Not Enrolled
Get Started


This e-learning course addresses an identified need to talk more and provide more information about the subtle progression in MS and the mechanisms behind uncovering it.

This module has two lead authors, both of them neurologists with extensive expertise in multiple sclerosis and members of ParadigMS Foundation.

You will receive a ParadigMS certificate upon completing the e-learning and successfully passing the exam. Should you not be able to download the certificate, or need any further information, please contact:

About this module

In this e-Learning section, ParadigMS Experts and highly respected MS neurologists, Prof. Carlo Pozzilli (IT) and Prof. Bart Van Wijmeersch (BE), provide an overview of the subtle progression in multiple sclerosis (MS) disease. The current approach to multiple sclerosis management is effective in controlling acute neuroinflammation, which drives relapse and acute lesions. Nowadays, relapses have become infrequent. In the absence of relapse, other important mechanisms are implicated in the disease progression, resulting in disability accumulation, known as smoldering neuroinflammation.

By the end of this e-learning module, participants will:

  • Differentiate between subclinical and subtle MS progression
  • Distinguish between progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW)
  • Recognise smouldering multiple sclerosis in the absence of clinical relapses
  • Understand PIRA frequency and its underlying pathological mechanisms as compared to RAW
  • Differentiate between pure PIRA and missed relapse activity
  • Understand the interdependencies of MS symptoms
  • Understand isolated cognitive relapses (ICRs)
  • Recognise Acute Pelvic floor dysfunctions
  • Differentiate between pure PIRA and missed MRI activity
  • Review promising MRI markers to identify PIRA

This module has been peer-reviewed by the following experts of ParadigMS Foundation: Prof. Laura Airas (FI), Prof. Florian Deisenhammer (AT), Prof. Nikolaos Grigoriadis (GR), Prof. Melinda Magyari (DE), Prof. Veronica Popescu (BE), Prof. Magd Zakaria (EG) and Prof. Patrick Vermersch (FR).

This elearning has been made possible thanks to the financial support of Sanofi without any influence on the content.

Educational slide decks
endorsed by experts

Minimum two MS experts collaborate to produce an educational slide deck. These slide decks are presented (live) to ParadigMS members, peer reviewed and updated.
The slide decks are published on the ParadigMS website “on behalf of ParadigMS”.

Consensus publications

Based on the slide decks, publications are produced. These publications are peer reviewed and published as consensus publications.

Regional and national educational events

Regional (fe: Scandinavian countries, Benelux, …) or national events where state-of-the-art science is transferred to general neurologists and other care givers (nurses, etc) that are confronted with MS in their day to day practice.

Web-based educational tools and resources

Webinars can complement the educational events.

Medical education (ME) programs

The educational slide decks, events and webinars can be important building blocks of accredited educational programs.


Do subscriptions auto-renew?
Your subscription will automatically renew on a monthly or yearly basis, depending on the plan you have chosen. If you cancel your plan, it will not renew at the end of your subscription cycle. It will end once the period you have paid for is over.
What happens if I subscribe as a healthcare practitioner if I am not a healthcare practitioner?
If you subscribe as a healthcare practitioner and it is proven that you are not a healthcare practitioner, you will be banned immediately from the community and could be liable to prosecution.
How can I cancel my trial or subscription?
You can cancel your trial or subscription in your account settings. If you cancel during the trial period you will not be charged.

Terms and Conditions

All the Terms and Conditions of the ParadigMS Foundation Website can be downloaded here.