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E-Learning: Part 2/5 on Microglia: Clinical progression and the relation with innate immune cells (Accredited by EACCME)

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Introduction

Microglia are a class of innate immune cells in the central nervous system (CNS). In the space of just a few years they have become a major focus of attention in multiple sclerosis (MS) research and as a therapeutic target to prevent disability progression in persons with MS.

This e-learning module is part of a series of 5 e-learning modules created by ParadigMS on ‘the role of Microglia in Multiple Sclerosis’. Each module has a lead author and several contributors, all are neurologists with an expertise in multiple sclerosis and members of ParadigMS.

You will receive an EACCME certificate and 0,5 European CME credit (ECMEC®) upon completing the e-learning and successfully passing the exam. Should you not be able to download the certificate, or need any further information, please contact: learning@paradigms.foundation

This self paced e-learning cover ‘clinical progression and the relation with innate immune cells’ in the context of Microglia.

About this module

The historical classification of multiple sclerosis in terms of different phenotypes (relapsing-remitting, secondary progressive, primary progressive) has led to their interpretation as separate entities characterised by acute inflammation in the relapsing form of the disease and chronic neuroinflammation in progressive forms. However, evidence now suggests that all phenotypes lie on an MS continuum, and that acute and chronic inflammation are present to different extents in each form.

Professor Carlo Pozzilli – ParadigMS Expert and noted Italian MS neurologist – digs down into the pathophysiology of MS to explain the MS continuum, showing how acute inflammation is caused by adaptive immune system cells entering the central nervous system from the periphery, while chronic neuroinflammation can be explained by the presence of compartmentalized immune cells trapped behind the blood-brain barrier. This latter phenomenon has implications for the activation of microglia in the brain and subsequent induction of neurodegenerative processes.

By the end of this e-learning module, participants will:
• Have a better understanding of the pathogenesis of MS

• Be able to explain the pathophysiological mechanisms associated with disease progression

• Understand why activated microglia  are destructive in progressive MS. 

Educational slide decks
endorsed by experts

Minimum two MS experts collaborate to produce an educational slide deck. These slide decks are presented (live) to ParadigMS members, peer reviewed and updated.
The slide decks are published on the ParadigMS website “on behalf of ParadigMS”.

Consensus publications

Based on the slide decks, publications are produced. These publications are peer reviewed and published as consensus publications.

Regional and national educational events

Regional (fe: Scandinavian countries, Benelux, …) or national events where state-of-the-art science is transferred to general neurologists and other care givers (nurses, etc) that are confronted with MS in their day to day practice.

Web-based educational tools and resources

Webinars can complement the educational events.

Medical education (ME) programs

The educational slide decks, events and webinars can be important building blocks of accredited educational programs.

FAQs

Do subscriptions auto-renew?
Your subscription will automatically renew on a monthly or yearly basis, depending on the plan you have chosen. If you cancel your plan, it will not renew at the end of your subscription cycle. It will end once the period you have paid for is over.
What happens if I subscribe as a healthcare practitioner if I am not a healthcare practitioner?
If you subscribe as a healthcare practitioner and it is proven that you are not a healthcare practitioner, you will be banned immediately from the community and could be liable to prosecution.
How can I cancel my trial or subscription?
You can cancel your trial or subscription in your account settings. If you cancel during the trial period you will not be charged.

Terms and Conditions

All the Terms and Conditions of the ParadigMS Foundation Website can be downloaded here.